Mapping the Transcriptomics Landscape of Post-Traumatic Stress Disorder Symptom Dimensions in World Trade Center Responders

Details

• Personal Author:
  Bromet E ; Che C ; Clouston S ; Glenn ST ; Gomez EC ; Kotov R ; Kuan P-F ; Luft BJ ; Ren X ; Singh PK ; Wang J ; Waszczuk M ; Yang X
• Description:
  Gene expression has provided promising insights into the pathophysiology of post-traumatic stress disorder (PTSD); however, specific regulatory transcriptomic mechanisms remain unknown. The present study addressed this limitation by performing transcriptome-wide RNA-Seq of whole-blood samples from 226 World Trade Center responders. The investigation focused on differential expression (DE) at the gene, isoform, and for the first time, alternative splicing (AS) levels associated with the symptoms of PTSD: total burden, re-experiencing, avoidance, numbing, and hyperarousal subdimensions. These symptoms were associated with 76, 1, 48, 15, and 49 DE genes, respectively (FDR < 0.05). Moreover, they were associated with 103, 11, 0, 43, and 32 AS events. Avoidance differed the most from other dimensions with respect to DE genes and AS events. Gene set enrichment analysis (GSEA) identified pathways involved in inflammatory and metabolic processes, which may have implications in the treatment of PTSD. Overall, the findings shed a novel light on the wide range of transcriptomic alterations associated with PTSD at the gene and AS levels. The results of DE analysis associated with PTSD subdimensions highlights the importance of studying PTSD symptom heterogeneity. [Description provided by NIOSH]
• Subjects:
  Blood Emergency Responders Energy Metabolism Genetics Hematologic Tests Immune System Mental Disorders Mental Health Occupational Health Pathology Safety September 11 Terrorist Attacks

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• Keywords:
  Blood Samples Emergency Responders Gene Expression Gene Regulation Genes Genetic Factors Genomics Humans Immune Reaction Mental Disorders Metabolic Effects Physiology Post-traumatic Stress Disorder Psychological Disorders PTSD Rescue Workers Ribonucleic Acids RNA Translational Research World Trade Center WTC

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• ISSN:
  2158-3188
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; New York ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• NIOSHTIC Number:
  nn:20062804
• Citation:
  Transl Psychiatry 2021 May; 11:310
• Contact Point Address:
  Pei-Fen Kuan, Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA
• Email:
  peifen.kuan@stonybrook.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Translational Psychiatry
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b266a0e3e6e9f83beb8e12e7870a3638abc731a0bcb163c0819393f36e8dc98aac5eda5055301ad634e738eb46dcf513488028a4f08f1f4fe56c900b18c5f5d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/225986/cdc_225986_DS1.pdf
• File Type:
  [PDF - 618.23 KB ]