Nanoparticles as a Tool in Neuro-Oncology Theranostics

Details

• Personal Author:
  Cavendish J ; Fladeland R ; Geldenhuys WJ ; Klein AL ; Lockman PR ; Nugent G ; Porter, Dale ; Sherman JH ; Sriram K
• Description:
  The rapid growth of nanotechnology and the development of novel nanomaterials with unique physicochemical characteristics provides potential for the utility of nanomaterials in theranostics, including neuroimaging, for identifying neurodegenerative changes or central nervous system malignancy. Here we present a systematic and thorough review of the current evidence pertaining to the imaging characteristics of various nanomaterials, their associated toxicity profiles, and mechanisms for enhancing tropism in an effort to demonstrate the utility of nanoparticles as an imaging tool in neuro-oncology. Particular attention is given to carbon-based and metal oxide nanoparticles and their theranostic utility in MRI, CT, photoacoustic imaging, PET imaging, fluorescent and NIR fluorescent imaging, and SPECT imaging. [Description provided by NIOSH]
• Subjects:
  Biopharmaceutics Diagnosis Drug Therapy Hazardous Substances Neoplasms Occupational Health Radiation Safety Toxicology
• Keywords:
  Author Keywords: Imaging Brain Tumors Carbon Nanotubes Central Nervous System CNT Diagnostic Techniques Drugs Drug Therapy Imaging Techniques Magnetic Resonance Imaging Malignancy Metal Oxides MRI Multi-walled Carbon Nanotubes MWCNT Nanoparticles Nanotechnology Nanotoxicology Nervous System Neuro-oncology Neuropharmacology Neurosurgery Oncogenic Agents Pharmaceuticals Radioactive Materials Surgery Systematic Reviews Theranostic Therapeutic Agents Toxic Materials

  More +
• ISSN:
  1999-4923
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  7
• NIOSHTIC Number:
  nn:20063056
• Citation:
  Pharmaceutics 2021 Jul; 13(7):948
• Contact Point Address:
  Jonathan H. Sherman, Department of Neuroscience, West Virginia University School of Medicine, Morgantown, WV 26506, USA
• Email:
  jsherman0620@gmail.com
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Pharmaceutics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fe2e1ab08e3ed4abadc726c34c3e0ed07ec7bcfbb5c34e3be3c0e6a1d63fddb19e6d7e8d3a303149ab5c801ec7e27c24be73547cbb7539da46aaeb0737d20a65
• Download URL:
  https://stacks.cdc.gov/view/cdc/226185/cdc_226185_DS1.pdf
• File Type:
  [PDF - 1.22 MB ]