Use of Gabapentinoid Medications Among US Adults with Cancer, 2005–2015

Details

• Personal Author:
  Choi SW ; Davis MA ; Fauer AJ ; Friese CR ; Wallner LP
• Description:
  Background: Gabapentinoid use for long-term cancer pain control may be problematic, given unclear mechanisms of action and increased concerns for physical dependence. The purpose of this report is to examine trends of gabapentinoid use among US adults with cancer from 2005 to 2015. Methods: We conducted a serial, cross-sectional study using data from the Medical Expenditure Panel Survey (MEPS). We performed multiple logistic regression to examine the annual percentages of gabapentinoid users, which were adjusted for age, sex, and US region of residence. The amount of gabapentinoid prescriptions filled in 2015 was also estimated. Results: The adjusted percentage of gabapentinoid users in 2015 was 5.60% (3.79%, 7.41%), 2.39 times greater than the percentage in 2005 (p < .001). By 2015, the number of gabapentinoid prescriptions had grown to approximately 3.52 million (2.40 million, 4.65 million). Conclusion: We observed greater than a twofold increase in the trend of gabapentinoid medication use among US adults with cancer. Investigations on the long-term efficacy of gabapentinoids for complex pain syndromes, and mitigation of risks, is essential to guide informed clinical management and keep patients safe. [Description provided by NIOSH]
• Subjects:
  Aging Biopharmaceutics Drug Therapy Epidemiology Neoplasms Nervous System Occupational Health Safety
• Keywords:
  Age Groups Analgesics Anticonvulsants Author Keywords: Cancer Cancer Cross Sectional Studies Drug Therapy Gabapentin Humans Medical Treatment Medicinal Chemicals Neoplastic Agents Nerves Nervous System Pain Tolerance Pharmaceuticals Practice Pattern Regression Analysis Supportive Care Therapeutic Agents

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• ISSN:
  0941-4355
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5-8
• Volume:
  28
• Issue:
  1
• NIOSHTIC Number:
  nn:20058752
• Citation:
  Support Care Cancer 2020 Jan; 28(1):5-8
• Contact Point Address:
  Alex J. Fauer, School of Nursing, University of Michigan, Ann Arbor, MI, USA
• Email:
  ajfau@umich.edu
• CAS Registry Number:
  Gabapentin (CAS RN 60142-96-3)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Supportive Care in Cancer
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6c18efb83b69518137f76929efc1567e9255c0912f183ad2ed4131a058ead7518362745798a7df7674a1c5a8c656dba5a35f8a014c40812f9ef5830f185c6a64
• Download URL:
  https://stacks.cdc.gov/view/cdc/223152/cdc_223152_DS1.pdf
• File Type:
  [PDF - 202.76 KB ]