Solvent-Based Paint and Varnish Removers: A Focused Toxicologic Review of Existing and Alternative Constituents

Details

• Personal Author:
  Clapp R ; Durrani T ; Harrison, Robert ; Shusterman D
• Description:
  Paint and varnish removers constitute a major potential source of organic solvent exposure to contractors and home improvement enthusiasts. Unfortunately, the leading paint remover formulations have traditionally contained, as major ingredients, chemicals classified as probable human carcinogens (eg, methylene chloride) or reproductive toxicants (eg, N-methylpyrrolidone). In addition, because of its unique toxicology (ie, hepatic conversion to carbon monoxide compounding generic solvent narcosis and arrythmogenesis), high volatility, and rigorous requirements for personal protective equipment, methylene chloride exposures from paint removers have been linked to numerous deaths involving both occupational and consumer usage. The aim of this review is to summarize the known toxicology of solvent-based paint remover constituents (including those found in substitute formulations) in order to provide health risk information to regulators, chemical formulators, and end-users of this class of products, and to highlight any data gaps that may exist. [Description provided by NIOSH]
• Subjects:
  Carcinogens Hazardous Substances Occupational Health Safety Solvents Toxicology Urogenital System
• Keywords:
  Author Keywords: Carboxyhemoglobin Carcinogen Chemical Hazards Health Hazards Methylene Chloride N-methyl Pyrrolidone Narcosis Organic Solvents Paint Remover Paint Removers Paint Stripper Reproductive Hazards Reproductive Toxicants Toxic Materials Varnish Remover

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• ISSN:
  0260-437X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  40
• Issue:
  10
• NIOSHTIC Number:
  nn:20063047
• Citation:
  J Appl Toxicol 2020 Oct; 40(10):1325-1341
• Contact Point Address:
  Timur Durrani, MD, MPH, MBA, Division of Occupational and Environmental Medicine, University of California, California Poison Control System - San Francisco Division, Campus Box 1369, San Francisco, CA 94143-1369, USA
• Email:
  timur.durrani@ucsf.edu
• CAS Registry Number:
  Dichloromethane (CAS RN 75-09-2) ; N-Methyl-2-pyrrolidone (CAS RN 872-50-4)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Applied Toxicology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07dae3bc6c5aa358fc02cbf65ef1bc1a23a8ce7ea382b973e3b6749c4a7de75cbade9114356ce6ac7b672c636038ac8089cc4509c844f4857f35c8c6fb67619e
• Download URL:
  https://stacks.cdc.gov/view/cdc/226176/cdc_226176_DS1.pdf
• File Type:
  [PDF - 1.17 MB ]