End-Stage Renal Disease and Metalworking Fluid Exposure

Details

• Personal Author:
  Applebaum KM ; Eisen EA ; Hammond SK ; LaValley MP ; Liu S ; Picciotto S ; Shrestha D ; Weiner DE
• Description:
  Objective: Despite increasing prevalence of end-stage renal disease (ESRD), little attention has been directed to how occupational exposures may contribute to risk. Our objective was to investigate the relationship between metalworking fluids (MWF) and ESRD in a cohort of 36 703 male autoworkers. Methods: We accounted for competing risk of death, using the subdistribution hazard approach to estimate subhazard ratios (sHRs) and 95% CIs in models with cubic splines for cumulative exposure to MWF (straight, soluble or synthetic). Results: Based on 501 ESRD cases and 13 434 deaths, we did not observe an association between MWF and ESRD overall. We observed modest associations between MWF and ESRD classification of glomerulonephritis and diabetic nephropathy. For glomerulonephritis, the 60th percentile of straight MWF was associated with an 18% increased subhazard (sHR=1.18, 95% CI: 0.99 to 1.41). For diabetic nephropathy, the subhazard increased 28% at the 60th percentile of soluble MWF (sHR=1.28, 95% CI: 1.00 to 1.64). Differences by race suggest that black males may have higher disease rates following MWF exposure. Conclusions: Exposure to straight and soluble MWF may be related to ESRD classification, though this relationship should be further examined. [Description provided by NIOSH]
• Subjects:
  Automobiles Environmental Exposure Men Mortality Occupational Health Race Factors Risk Assessment Risk Factors Safety
• Keywords:
  Automotive Industry Exposure Levels Fatalities Humans Metalworking Fluids MWFs Racial Factors Renal Toxicity Risk Factors
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; District of Columbia ; Indiana ; Massachusetts ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  24-31
• Volume:
  79
• Issue:
  1
• NIOSHTIC Number:
  nn:20063027
• Citation:
  Occup Environ Med 2022 Jan; 79(1):24-31
• Contact Point Address:
  Dr Katie M Applebaum, George Washington University, Milken Institute School of Public Health, Department of Environmental and Occupational Health, Washington, District of Columbia DC 20052
• Email:
  kapplebaum@gwu.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  George Washington University, Washington, DC
• Peer Reviewed:
  True
• Start Date:
  20130901
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:23c1e9c7357497eca5c9bff48d055610767339b92205d260fae676667ba23546d7918bc7a9af9871e6dd47d81b611fa5a10a3c049d6799d0a17af4bda5d239b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/226158/cdc_226158_DS1.pdf
• File Type:
  [PDF - 349.95 KB ]