Prostate Cancer Incidence in Relation to Time Windows of Exposure to Metalworking Fluids in the Auto Industry

Details

• Personal Author:
  Agalliu I ; Eisen EA ; Kriebel D ; Quinn, Margaret M. ; Wegman, David H.
• Description:
  Background: Exposure to metalworking fluids has been previously associated with prostate cancer mortality in a cohort of autoworkers. Our objective was to further explore this finding in a study of prostate cancer incidence in the same cohort, with reduced misclassification of outcome. Methods: We conducted a nested case-control study in the General Motors cohort of autoworkers. Incident cases of prostate cancer (n -872) were identified via the Michigan Cancer Registry from 1985 through 2000. Controls were selected using incidence-density sampling with 5:1 ratio. Using cumulative exposure (mg/m3-years) as the dose metric, we first examined varying lengths of lags (0-25 years). Then, we evaluated consecutive windows of exposure: 25 or more years before risk age, and fewer than 25 years. We used penalized splines to model the relative risk as a smooth function of exposure, and adjusted for race and calendar year of diagnosis in a Cox model. Results: Risk of prostate cancer increased with exposure to soluble and straight fluids 25 years or more before risk age but not with exposure in the last 25 years. The relationship with soluble fluids was piecewise linear, with a small increase in risk at lower exposures followed by a steeper rise. By contrast, the relationship with straight fluids was linear, with a relative risk of 1.12 per 10 mg/m3-years of exposure (95% confidence interval - 1.04-1.20). Conclusions: Exposure to oil-based fluids, soluble and straight, is modestly associated with prostate cancer risk among autoworkers, with a latency period of at least 25 years. [Description provided by NIOSH]
• Subjects:
  Aging Automobiles Carcinogens Endocrine System Environmental Exposure Morbidity Mortality Neoplasms Occupational Health Race Factors Risk Assessment Risk Factors Safety

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• Keywords:
  Age Groups Automotive Industry Biological Effects Cancer Carcinogenesis Exposure Levels Fluids Hormones Metalworking Fluids Models Morbidity Rates Mortality Rates MWFs Oils Prostate Cancer Racial Factors Risk Factors

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• ISSN:
  1044-3983
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20054198
• Citation:
  Epidemiology 2005 Sep; 16(5):664-671
• Contact Point Address:
  Ellen A. Eisen, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115
• Email:
  eeisen@hsph.harvard.edu
• Federal Fiscal Year:
  2005
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20030731
• Source Full Name:
  Epidemiology
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fefff7d78ee9815cd21c3aedbe613cbfed2024bd2151cf2c5dba82554a5d9ce466cfec2f0da557ec037e1c8591b52943b2c2d521579731207a640400cbefa10f
• Download URL:
  https://stacks.cdc.gov/view/cdc/216810/cdc_216810_DS1.pdf
• File Type:
  [PDF - 406.21 KB ]