Human IgG and IgA Responses to COVID-19 mRNA Vaccines

Details

• Personal Author:
  Campillo Luna J ; Redlich CA ; Wisnewski AV
• Description:
  SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity, however, limited information exists on vaccine induced responses. We measured COVID-19 mRNA vaccine induced IgG and IgA in serum serially, up to 145 days post vaccination in 4 subjects. Spike antigen-specific IgG levels rose exponentially and plateaued 21 days after the initial vaccine dose. After the second vaccine dose IgG levels increased further, reaching a maximum approximately 7-10 days later, and remained elevated (average of 58% peak levels) during the additional >100 day follow up period. COVID-19 mRNA vaccination elicited spike antigen-specific IgA with similar kinetics of induction and time to peak levels, but more rapid decline in serum levels following both the 1st and 2nd vaccine doses (<18% peak levels within 100 days of the 2nd shot). The data demonstrate COVID-19 mRNA vaccines effectively induce spike antigen specific IgG and IgA and highlight marked differences in their persistence in serum. [Description provided by NIOSH]
• Subjects:
  Antibodies Antigens Blood Communicable Diseases Immune System Occupational Health Safety Viral Diseases
• Keywords:
  Blood Serum Coronavirus COVID-19 Dose Response Humans Immunoglobulins Infectious Agents Infectious Diseases Ribonucleic Acids RNA SARS-CoV-2 Serology Vaccines Viral Diseases Viral Infections

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• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  6
• NIOSHTIC Number:
  nn:20063007
• Citation:
  PLoS One 2021 Jun; 16(6):e0249499
• Contact Point Address:
  Adam V. WisnewskiI, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
• Email:
  adam.wisnewski@yale.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  Yale University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  PLoS One
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ae50fab9a94e37207c393575251466defa0da9a0e4b411ff7ac8fde94a2c270059cef2070fc8f90f7b3be6b6b892294cf7dc7d96deda389bbf0283e3667fe1ac
• Download URL:
  https://stacks.cdc.gov/view/cdc/226144/cdc_226144_DS1.pdf
• File Type:
  [PDF - 614.79 KB ]