Vishniacozyma victoriae (Syn. Cryptococcus victoriae) in the Homes of Asthmatic and Non-Asthmatic Children in New York City

Details

• Personal Author:
  Acosta L ; Cochran SJ ; Croston TL ; Dannemiller KC ; Divjan A ; Green, Brett J. ; Haines SR ; Miller RL ; Perzanowski MS ; Rundle AG ; Rush RE
• Description:
  Background: Indoor environments contain a broad diversity of non-pathogenic Basidiomycota yeasts, but their role in exacerbating adverse health effects has remained unclear. Objective: To understand the role of Vishniacozyma victoriae exposure and its impact on human health. Methods: A qPCR assay was developed to detect and quantify an abundant indoor yeast species, Vishniacozyma victoriae (syn. Cryptococcus victoriae), from homes participating in the New York City Neighborhood Asthma and Allergy Study (NAAS). We evaluated the associations between V. victoriae, housing characteristics, and asthma relevant health endpoints. Results: V. victoriae was quantified in 236 of the 256 bedroom floor dust samples ranging from less than 300-45,918 cell equivalents/mg of dust. Higher concentrations of V. victoriae were significantly associated with carpeted bedroom floors (P = 0.044), mean specific humidity (P = 0.004), winter (P < 0.0001) and spring (P = 0.001) seasons, and the presence of dog (P = 0.010) and dog allergen Can f 1 (P = 0.027). V. victoriae concentrations were lower in homes of children with asthma vs. without asthma (P = 0.027), an association observed only among the non-seroatopic children. [Description provided by NIOSH]
• Subjects:
  Air Pollution, Indoor Asthma Asthma, Occupational Biological Assay Dust Environmental Exposure Epidemiology Hypersensitivity Occupational Health Safety
• Keywords:
  Allergens Allergies Author Keywords: Allergy Bioassays Children Cryptococcus Dust Analysis Dusts Environmental Exposure Exposure Assessment Indoor Air Pollution Indoor Environments ITS QPCR Yeast Yeasts

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• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Interagency Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; Ohio ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  48-59
• Volume:
  32
• Issue:
  1
• NIOSHTIC Number:
  nn:20062918
• Citation:
  J Expo Sci Environ Epidemiol 2022 Jan; 32(1):48-59
• Contact Point Address:
  Brett J. Green, Office of the Director, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA
• Email:
  dox6@cdc.gov
• Federal Fiscal Year:
  2022
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3c7c147491b3a29b5f1067283efd42eaed952a3ac5b064d6273497371379716a7e94fe08e729815fe675d3097751ffe768f058f83d3a3a82ec3baf0c4ddb1356
• Download URL:
  https://stacks.cdc.gov/view/cdc/226086/cdc_226086_DS1.pdf
• File Type:
  [PDF - 827.50 KB ]