Volume of Malignant Melanoma Is Superior to Thickness as a Prognostic Indicator: Preliminary Observation

Details

• Personal Author:
  Bart RS ; Friedman RJ ; Grin CM ; Harris MN ; Heilman E ; Kamino H ; Kopf AW ; Levenstein MJ ; Postel AH ; Rigel DS ; Roses DF
• Description:
  There are many clinical and histologic factors that are known to be valuable in predicting survival rates for patients with cutaneous malignant melanomas. Breslow thickness is considered to be the most reliable prognostic factor; however, thickness is a unidimensional measurement. A more accurate mensuration to predict biologic behavior might be one that takes into account the three-dimensional volume of the neoplasm. In a study of 35 primary malignant melanomas, the volumes of the dermal components of the tumors were calculated. Those patients with tumor volumes of 200 mm3 or less had a 91.4% 5-year disease-free survival rate, compared with survival rate of only 16.7% for those patients whose lesions had tumor volumes exceeding 200 mm3. On multivariate analysis, tumor volume exceeded thickness as a prognostic indicator. Thus, measurement of tumor volume proved to be of greater significance than thickness in predicting the outcome for patients with malignant melanomas. [Description provided by NIOSH]
• Subjects:
  Neoplasms Occupational Health Safety Skin Skin Diseases
• Keywords:
  Clinical Pathology Malignancy Medical Screening Skin Cancer Skin Lesions Survival Rate
• ISSN:
  0733-8635
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  4
• NIOSHTIC Number:
  nn:20062891
• Citation:
  Dermatol Clin 1991 Oct; 9(4):643-648
• Contact Point Address:
  Robert J. Friedman, MD, Dermpath, Inc., 2 Overhill Road, Suite 311, Scarsdale, NY 10583
• Federal Fiscal Year:
  1992
• Performing Organization:
  New York University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  Dermatologic Clinics
• End Date:
  19820331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eb03b96a07fce993f497517de7727ad6d4808c71757cb2df92fcf3075fed229bd06b75c07c536bb3324b7e3690cd551c21baa9470b062255af501b01f55c8db1
• Download URL:
  https://stacks.cdc.gov/view/cdc/226062/cdc_226062_DS1.pdf
• File Type:
  [PDF - 657.54 KB ]