Prospective Follow-Up for Malignant Melanoma in Patients with Atypical-Mole (Dysplastic-Nevus) Syndrome

Details

• Personal Author:
  Bart RS ; Friedman RJ ; Gottlieb GJ ; Grin CM ; Kopf AW ; Levenstein MJ ; Rigel DS ; Tiersten AD
• Description:
  A total of 357 white patients who had melanocytic nevi that fulfilled the clinical criteria for the "classic" atypical-mole (dysplastic-nevus) syndrome (100 or more melanocytic nevi; one or more melanocytic nevi 8 mm or larger in diameter; and, one or more melanocytic nevi with atypical features) were followed for the development of cutaneous malignant melanomas. Seventeen patients (4.8%) developed malignant melanomas during an average follow-up period of 49 months. One patient developed two malignant melanomas. Eight of the malignant melanomas detected were in situ and ten were invasive melanomas (<0.86 mm in Breslow thickness), implying an excellent prognosis. The number of malignant melanomas detected in these patients exceeded significantly the number expected to occur in age-and sex-matched white controls. All groups were shown to have an increased risk for the development of malignant melanomas. Total-body photographs were helpful in detecting changes in size, shape, and color that led to the diagnosis of malignant melanoma. These data support the concept that patients with this readily regionalized clinical presentation of classic atypical-mole syndrome are at an increased risk for malignant melanomas and, therefore, should be examined regularly. [Description provided by NIOSH]
• Subjects:
  Neoplasms Occupational Health Safety Skin Skin Diseases
• Keywords:
  Malignancy Medical Examinations Medical Screening Skin Cancer Skin Lesions
• ISSN:
  0148-0812
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  44-48
• Volume:
  17
• Issue:
  1
• NIOSHTIC Number:
  nn:20058021
• Citation:
  J Dermatol Surg Oncol 1991 Jan; 17(1):44-48
• Contact Point Address:
  Alfred W. Kopf, MD, Oncology Section, Skin and Cancer Unit, New York University Medical Center, 562 First Avenue, New York, NY 10016
• Federal Fiscal Year:
  1991
• Performing Organization:
  New York University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  The Journal of Dermatologic Surgery and Oncology
• End Date:
  19820331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4361a5a2b572b4d285db389ffb11b1ddb3373ef6091671e1aefb5b6c59d7ed1b712e6aa137cb3bebcf1ee5dc6e003f6d6f8dbd17629e7136ea0f1c63721db290
• Download URL:
  https://stacks.cdc.gov/view/cdc/215213/cdc_215213_DS1.pdf
• File Type:
  [PDF - 494.64 KB ]