A Longitudinal Study of Indoor Nitrogen Dioxide Levels and Respiratory Symptoms in Inner-City Children with Asthma

Details

• Personal Author:
  Breysse PN ; Cuhran JL ; Curtin-Brosnan J ; Diette GB ; Hansel NN ; Matsui EC ; McCormack MC ; Moore JL ; Williams DL
• Description:
  Background: The effect of indoor nitrogen dioxide concentrations on asthma morbidity among inner-city preschool children is uncertain. Objectives: Our goal was to estimate the effect of indoor NO2 concentrations on asthma morbidity in an inner-city population while adjusting for other indoor pollutants. Methods: We recruited 150 children (2-6 years of age) with physician-diagnosed asthma from inner-city Baltimore, Maryland. Indoor air was monitored over a 72-hr period in the children's bedrooms at baseline and 3 and 6 months. At each visit, the child's caregiver completed a questionnaire assessing asthma symptoms over the previous 2 weeks and recent health care utilization. Results: Children were 58% male, 91% African American, and 42% from households with annual income < $25,000; 63% had persistent asthma symptoms. The mean (+/- SD) in-home NO2 concentration was 30.0 +/- 33.7 (range, 2.9-394.0) ppb. The presence of a gas stove and the use of a space heater or oven/stove for heat were independently associated with higher NO2 concentrations. Each 20-ppb increase in NO2 exposure was associated significantly with an increase in the number of days with limited speech [incidence rate ratio (IRR) = 1.15; 95% confidence interval (CI), 1.05-1.25], cough (IRR = 1.10; 95% CI, 1.02-1.18), and nocturnal symptoms (IRR = 1.09; 95% CI, 1.02-1.16), after adjustment for potential confounders. NO2 concentrations were not associated with increased health care utilization. Conclusions: Higher indoor NO2 concentrations were associated with increased asthma symptoms in preschool inner-city children. Interventions aimed at lowering NO2 concentrations in inner-city homes may reduce asthma morbidity in this vulnerable population. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Asthma Asthma, Occupational Morbidity Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Air Pollutants Air Pollution Author Keywords: Asthma Children IAQ Indoor Air Quality Indoor Pollutants Inner City Longitudinal Study Morbidity Rates Nitrogen Dioxide Nitrogen Dioxides Preschool Respiratory System Disorders

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  116
• Issue:
  10
• NIOSHTIC Number:
  nn:20062852
• Citation:
  Environ Health Perspect 2008 Oct; 116(10):1428-1432
• Contact Point Address:
  G.B. Diette, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument St., Baltimore, MD 21205 USA
• Email:
  gdiette@mail.jhmi.edu
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2009
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b76db379dcfd4be660e627de17b63249516dc3d7b4344ade00bf4d98e6a7255f0e9018b8d50cf755059d2d75fbc58b92a9142efd5f046850b3fb74c96addea39
• Download URL:
  https://stacks.cdc.gov/view/cdc/226027/cdc_226027_DS1.pdf
• File Type:
  [PDF - 135.35 KB ]