Urinary and Salivary Endocrine Measurements to Complement Tanner Staging in Studies of Pubertal Development

Details

• Personal Author:
  Barker-Cummings C ; Ciesielski Jones AJ ; Cousins DS ; Goldberg M ; Kesner JS ; Kipling LM ; Marcus M ; McGrath JA ; Meadows JW ; Monteilh C ; Sandler DP
• Description:
  Background: Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development. Objective: Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage. Methods: Thirty-five girls and 42 boys aged 7 to 15 years were enrolled in the Growth and Puberty (GAP) study, a longitudinal pilot study conducted from 2007-2009 involving children of women enrolled in the Agricultural Health Study (AHS) in Iowa. We collected saliva and urine samples and assessed pubertal development by self-rated Tanner staging (pubic hair, breast development (girls), genital development (boys)) at three visits over six months. We measured dehydroepiandrosterone (DHEA) in saliva and creatinine-adjusted luteinizing hormone (LH), testosterone, follicle stimulating hormone (FSH), estrone 3-glucuronide (E13G) and pregnanediol 3-glucuronide (Pd3G) concentrations in first morning urine. We evaluated the relationships over time between Tanner stage and each biomarker using repeated measures analysis. Results: Among girls still reporting Tanner breast stage 1 at the final visit, FSH levels increased over the 6-month follow-up period and were no longer lower than higher stage girls at the end of follow-up. We observed a similar pattern for testosterone in boys. By visit 3, boys still reporting Tanner genital stage 1 or pubic hair stage 1 had attained DHEA levels that were comparable to those among boys reporting Tanner stages 2 or 3. Conclusions: Increasing concentrations of FSH in girls and DHEA and testosterone in boys over a 6- month period revealed the start of the pubertal process prior to changes in self-rated Tanner stage. Repeated, non-invasive endocrine measures may complement the more subjective assessment of physical markers in studies determining pubertal onset [Description provided by NIOSH]
• Subjects:
  Biomarkers Endocrine System Occupational Health Safety Urine
• Keywords:
  Children Endocrine Function Endocrine System Hormones Humans Salivary Glands
• ISSN:
  1932-6203
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20062755
• Citation:
  PLoS One 2021 May; 16(5):e0251598
• Contact Point Address:
  Mandy Goldberg, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
• Email:
  mandy.goldberg@nih.gov
• Federal Fiscal Year:
  2021
• Peer Reviewed:
  True
• Source Full Name:
  PLoS One
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:23fb5b281c5268800966fc0ef56481bcde7c59160edae4df9fb04da4406c0e3153d95cb6af58b2869aaee9914c50252fdbff099d3ba4bafbf06e58cb4439360d
• Download URL:
  https://stacks.cdc.gov/view/cdc/225945/cdc_225945_DS1.pdf
• File Type:
  [PDF - 1.03 MB ]