Preliminary Risk Assessment for Acrylamide and Peripheral Neuropathy

Details

• Personal Author:
  Park RM
• Description:
  Acrylamide (ACM) is a high-volume industrial chemical with diverse uses in manufacturing, construction and laboratory research. ACM is a well-established neurotoxic agent causing peripheral neuropathy with impairment in the arms and legs of exposed workers, most thoroughly studied in Swedish tunnel workers exposed to ACM grouting. A quantitative risk assessment was performed to assess ACM risk to workers. Using data from a published paper investigating peripheral neuropathies in Chinese chemical workers, estimates of exposure response for vibration perception threshold and nerve conduction velocities were calculated, based on hemoglobin adducts and air concentrations as exposure metrics. The benchmark dose procedure was applied in order to calculate excess risks of impairment, defined as adverse performance exceeding the 95th percentile in unexposed populations, at various concentrations of airborne ACM exposure. Under the assumptions in this risk assessment, after three years of inhalation exposure at 0.3 mg/m3 , the excess attributable impairment manifest in vibration perception and nerve conduction velocity is estimated to occur in 1-2% of workers. For 10 years at 0.3 mg/m3 ACM inhalation (equivalent to 3 years at 1.0 mg/m3) the excess prevalence of impairment would be 2-14% of workers, assuming the effect continues to accrue linearly in time. Using published data, the risks of impairment from peripheral neuropathy attributable to exclusively airborne ACM exposure can be predicted for exposure periods less than 10 years. The risks associated with dermal and airborne ACM exposures can be estimated by characterizing working process environments using ACM Hb-adduct levels and possibly monitored with urinary biomarkers. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Construction Industry Environmental Exposure Hazardous Substances Laboratories Manufacturing And Industrial Facilities Musculoskeletal System Nervous System Occupational Health Particulate Matter Respiratory System Risk Assessment Risk Factors Safety Skin Urine Vibration Workplace

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• Keywords:
  Acrylamide Airborne Particulates Author Keywords: Benchmark Dose Chemical Hazards Chemicals Construction Dermal Exposures Environmental Exposure Exposure Levels Exposure Response Extremities Hemoglobin Adduct Inhalation Manufacturing Nerve Conduction Velocity Nerves Neuropathy Neurotoxic Effects Peripheral Nervous System Risk Assessment Risk Factors Urinalysis Urine Chemistry Vibration Exposure Vibration Perception Threshold Work Environment Workers

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• ISSN:
  0161-813X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  10-17
• Volume:
  85
• NIOSHTIC Number:
  nn:20062749
• Citation:
  Neurotoxicology 2021 Jul; 85:10-17
• Contact Point Address:
  Robert M. Park, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Division for Science Integration, Risk Evaluation Branch, 1090 Tusculum Ave, MS C-15, Cincinnati, OH 45226-1998
• Email:
  rhp9@cdc.gov
• CAS Registry Number:
  Acrylamide (CAS RN 79-06-1)
• Federal Fiscal Year:
  2021
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f68fb24872546fd9d81c39690e2cb49d0f2c5318039ce57d17d249fa1a7280422882f3434ee5ef2fb09243a27c5db804cffac0576d937a5fd8fae8e83d9fdb2b
• Download URL:
  https://stacks.cdc.gov/view/cdc/225939/cdc_225939_DS1.pdf
• File Type:
  [PDF - 1.12 MB ]