Details:

Alternative Title:
Neurotoxicology
Personal Author:
Park, Robert M.
Description:
Acrylamide (ACM) is a high-volume industrial chemical with diverse uses in manufacturing, construction and laboratory research. ACM is a well-established neurotoxic agent causing peripheral neuropathy with impairment in the arms and legs of exposed workers, most thoroughly studied in Swedish tunnel workers exposed to ACM grouting. A quantitative risk assessment was performed to assess ACM risk to workers. Using data from a published paper investigating peripheral neuropathies in Chinese chemical workers, estimates of exposure response for vibration perception threshold and nerve conduction velocities were calculated, based on hemoglobin adducts and air concentrations as exposure metrics. The benchmark dose procedure was applied in order to calculate excess risks of impairment, defined as adverse performance exceeding the 95| percentile in unexposed populations, at various concentrations of airborne ACM exposure. Under the assumptions in this risk assessment, after three years of inhalation exposure at 0.3 mg/m|, the excess attributable impairment manifest in vibration perception and nerve conduction velocity is estimated to occur in 1-2% of workers. For 10 years at 0.3 mg/m| ACM inhalation (equivalent to 3 years at 1.0 mg/m|) the excess prevalence of impairment would be 2-14% of workers, assuming the effect continues to accrue linearly in time. Using published data, the risks of impairment from peripheral neuropathy attributable to exclusively airborne ACM exposure can be predicted for exposure periods less than 10 years. The risks associated with dermal and airborne ACM exposures can be estimated by characterizing working process environments using ACM Hb-adduct levels and possibly monitored with urinary biomarkers.
Subjects:
[+]
Acrylamide Adolescent Adult Article Benchmark Dose Chemical Industry China Exposure Response Female Hemoglobin Adduct Humans Inhalation Exposure Male Nerve Conduction Velocity Neural Conduction Neurotoxicity Syndromes Occupational Exposure Peripheral Nervous System Diseases Risk Assessment Sweden Vibration Perception Threshold Young Adult
Source:
Neurotoxicology. 85:10-17
Pubmed ID:
33892018
Pubmed Central ID:
PMC8284192
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fbbc8640ca4083a6ec77b249ad8182745a0ff5505d79d5a552ee1f3e01bfa107
Download URL:
https://stacks.cdc.gov/view/cdc/118712/cdc_118712_DS1.pdf
File Type:

Supporting Files

• 	nihms-1718110.nxml	xml
  	NIHMS1718110-supplement-Supplementary_Material.docx	docx

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