Indoor Particulate Matter Increases Asthma Morbidity in Children with Non-Atopic and Atopic Asthma

Details

• Personal Author:
  Breysse PN ; Curtin-Brosnan J ; Diette GB ; Hansel NN ; Matsui EC ; McCormack MC ; Peng RD ; Williams DL ; Wills-Karp M ; Breysse PN ; Curtin-Brosnan J ; Diette GB ; Hansel NN ; Matsui EC ; McCormack MC ; Peng RD ; Williams DL ; Wills-Karp M
• Corporate Authors:
  Center for Childhood Asthma in the Urban Environment ; Center for Childhood Asthma in the Urban Environment
• Description:
  Background: Compared with atopic asthma, fewer environmental modifications are recommended for non-atopic asthma in children. Objective: To better understand the role of indoor pollutants in provoking non-atopic asthma, we investigated the effect of in-home particulate matter on asthma symptoms among non-atopic and atopic children living in inner-city Baltimore. Methods: A cohort of 150 children ages 2 to 6 years with asthma underwent home environmental monitoring for 3-day intervals at baseline, 3, and 6 months. Children were classified as non-atopic if they were skin test negative to a panel of 14 aeroallergens. Caregivers completed questionnaires assessing symptoms and rescue medication use. Longitudinal data analysis included regression models with generalized estimating equations. Results: Children were primarily African American from lower socioeconomic backgrounds and spent most of their time in the home. Thirty-one percent were non-atopic, and 69% were atopic. Among non-atopic and atopic children, increased in-home fine (PM2.5) and coarse (PM2.5-10) particle concentrations were associated with significant increases in asthma symptoms and rescue medication use ranging from 7% (95% confidence interval [CI], 0-15) to 14% (95% CI, 1-27) per 10 microg/m3 increase in particle concentration after adjustment for confounders. Conclusions: In-home particles similarly cause increased symptoms of asthma in non-atopic and atopic children. Environmental control strategies that reduce particle concentrations may prove to be an effective means of improving asthma outcomes, especially for non-atopic asthma, for which there are few environmental control practice recommendations. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Asthma Asthma, Occupational Cohort Studies Environment Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Airborne Particles Children Cohort Studies Environmental Factors IAQ Indoor Air Quality Particulates Respiratory Diseases
• ISSN:
  1081-1206
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  308-315
• Volume:
  106
• Issue:
  4
• NIOSHTIC Number:
  nn:20062713
• Citation:
  Ann Allergy Asthma Immunol 2011 Apr; 106(4):308-315
• Contact Point Address:
  Meredith C. McCormack, MD MHS, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, East Monument Street, 5th Floor, Baltimore, MD 21205
• Email:
  Mmccor16@jhmi.edu
• Federal Fiscal Year:
  2011
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Allergy, Asthma and Immunology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:70939c6ccb8d10ae0828c212bdd3fc8e60416ecd4604d4500d1c09081c1cad704fbf8945fb3d0192a21e35ff70ffe9c6f145fefb16341e8aacb0fbd7d3a3b8cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/225907/cdc_225907_DS1.pdf
• File Type:
  [PDF - 519.95 KB ]