Transport of Metal Oxide Nanoparticles and Single-Walled Carbon Nanotubes in Human Mucus

Details

• Personal Author:
  Biswal S ; Breysse PN ; Hanes J ; Hida K ; Jachak A ; Lai SK ; Markovic N ; Suk JS
• Description:
  Whether mucus layers lining entrance points into the body, including the lung airways, provide protection against the penetration of engineered nanoparticles remains poorly understood. We measured the diffusion coefficients of hundreds of individual nanoparticles of three different metal oxides (nMeOs) and two types of single-walled carbon nanotubes (SWCNTs) in undiluted human mucus. We found that the vast majority of these nanoparticles are efficiently trapped in human mucus and, further, that the mechanism of trapping is adhesive interactions as opposed to steric obstruction. However, a small fraction of zinc oxide (ZnO) nanoparticles moved at rates fast enough to penetrate airway mucus layers. We conclude that human mucus layers probably provide considerable protection for mucosal tissues from the penetration of most nMeOs and SWCNTs, and suggest that further investigation of the potential health risks of exposure to ZnO nanoparticles is warranted. [Description provided by NIOSH]
• Subjects:
  Lung Occupational Health Respiratory System Safety Sense Organs Toxicology
• Keywords:
  Author Keywords: Nanotoxicology Metal Oxides Mucous Membranes Nanoparticles Nanotoxicology Reactive Oxygen Species ROS Single-walled Carbon Nanotubes SWCNT
• ISSN:
  1743-5390
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  6
• Issue:
  6
• NIOSHTIC Number:
  nn:20062699
• Citation:
  Nanotoxicology 2012 Sep; 6(6):614-622
• Contact Point Address:
  Justin Hanes, The Center for Nanomedicine and the Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 400 N. Broadway Street, Baltimore, MD 21231, USA
• Email:
  hanes@jhu.edu
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6) ; Zinc oxide (ZnO) (CAS RN 1314-13-2)
• Federal Fiscal Year:
  2012
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Nanotoxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c90ca8b95d7971d68a684fabc2d0ab6fb636c149b6be370c2cf03d1ca524f92af595f2ce1882d4fae84930bd0450dd391436ecb41a0e7ecd73c013b672d7276d
• Download URL:
  https://stacks.cdc.gov/view/cdc/225895/cdc_225895_DS1.pdf
• File Type:
  [PDF - 710.77 KB ]