A Critical Review on the Potential Impacts of Neonicotinoid Insecticide Use: Current Knowledge of Environmental Fate, Toxicity, and Implications for Human Health

Details

• Personal Author:
  Cwiertny DM ; Field RW ; Hladik ML ; Kolpin DW ; LaDuca LE ; LeFevre GH ; Lehmler H-J ; Peeples TL ; Poch MC ; Schilling KE ; Thompson DA ; Vargo JD
• Description:
  Neonicotinoid insecticides are widely used in both urban and agricultural settings around the world. Historically, neonicotinoid insecticides have been viewed as ideal replacements for more toxic compounds, like organophosphates, due in part to their perceived limited potential to affect the environment and human health. This critical review investigates the environmental fate and toxicity of neonicotinoids and their metabolites and the potential risks associated with exposure. Neonicotinoids are found to be ubiquitous in the environment, drinking water, and food, with low-level exposure commonly documented below acceptable daily intake standards. Available toxicological data from animal studies indicate possible genotoxicity, cytotoxicity, impaired immune function, and reduced growth and reproductive success at low concentrations, while limited data from ecological or cross-sectional epidemiological studies have identified acute and chronic health effects ranging from acute respiratory, cardiovascular, and neurological symptoms to oxidative genetic damage and birth defects. Due to the heavy use of neonicotinoids and potential for cumulative chronic exposure, these insecticides represent novel risks and necessitate further study to fully understand their risks to humans. [Description provided by NIOSH]
• Subjects:
  Environmental Pollution Insecticides Occupational Exposure Occupational Health Safety
• Keywords:
  Chronic Exposure Drinking Water Ecological Systems Environmental Contamination Environmental Impacts Health Effects Pesticides And Agricultural Chemicals
• ISSN:
  2050-7887
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Iowa ; OSHA Region 3 ; OSHA Region 7 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  6
• NIOSHTIC Number:
  nn:20062639
• Citation:
  Environ Sci Process Impacts 2020 Jun; 22(6):1315-1346
• Contact Point Address:
  Darrin A. Thompson, University of Iowa, College of Public Health, Iowa City, IA, USA
• Email:
  Darrin-thompson-1@uiowa.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Science: Processes & Impacts
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9eee8b251ba9a8913ca20bf66f94cc8cc6e4b9d952478d33105d0fff1b53fe872da611230e7c87e9c5e6535cce82c50f49ed190e1216f98d8ce8f45b38474d97
• Download URL:
  https://stacks.cdc.gov/view/cdc/225844/cdc_225844_DS1.pdf
• File Type:
  [PDF - 1.49 MB ]