Antimicrobial Resistance in Enteric Bacteria: Current State and Next-Generation Solutions

Details

• Personal Author:
  Dantas G ; Fishbein SRS ; Wallace MJ
• Description:
  Antimicrobial resistance is one of the largest threats to global health and imposes substantial burdens in terms of morbidity, mortality, and economic costs. The gut is a key conduit for the genesis and spread of antimicrobial resistance in enteric bacterial pathogens. Distinct bacterial species that cause enteric disease can exist as invasive enteropathogens that immediately evoke gastrointestinal distress, or pathobionts that can arise from established bacterial commensals to inflict dysbiosis and disease. Furthermore, various environmental reservoirs and stressors facilitate the evolution and transmission of resistance. In this review, we present a comprehensive discussion on circulating resistance profiles and gene mobilization strategies of the most problematic species of enteric bacterial pathogens. Importantly, we present emerging approaches toward surveillance of pathogens and their resistance elements as well as promising treatment strategies that can circumvent common resistance mechanisms. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety
• Keywords:
  Antimicrobial Resistance Antimicrobials Author Keywords: Antimicrobial Resistance Bacteria Bacterial Infections Enteric Pathogen Gastrointestinal System Genomics High-throughput Sequencing Metagenomics Mobile Genetic Element Pathobiont Pathogens Whole-genome Sequencing

  More +
• ISSN:
  1949-0976
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Missouri ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  1
• NIOSHTIC Number:
  nn:20062579
• Citation:
  Gut Microbes 2020 Nov; 12(1):1799654
• Contact Point Address:
  G. Dantas, Department of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO
• Email:
  dantas@wustl.edu
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Washington University, Saint Louis
• Peer Reviewed:
  True
• Start Date:
  20180901
• Source Full Name:
  Gut Microbes
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aa898303f1665d12dce3616dd4b2fe8d00922341f9bbd8e0b49b15b19cefeb455b3be99812ad72fabbb0897d1aaaf1a77d9361ab178c353ce2db6d051e160560
• Download URL:
  https://stacks.cdc.gov/view/cdc/225792/cdc_225792_DS1.pdf
• File Type:
  [PDF - 1.62 MB ]