Editorial: Immune Mechanisms in the Pathologic Response to Particles, Fibers, and Nanomaterials

Details

• Personal Author:
  Brown JM ; Italiani P ; Ma Q ; Moghimi SM ; Pollard KM
• Description:
  It may come as a surprise that a Research Topic in Frontiers in Immunology is devoted to "Immune mechanisms" in the pathologic response to "particles, fibers, and nanomaterials," a large group of natural and man-made particulates with dimensions in micro and nano ranges. Unlike pathogens, many particulate materials do not possess apparent antigenic structures and are assumed to be non-immunogenic. But because of their small size and airborne propensity, inhaled particulates can penetrate deep into the lung and pleura to cause inflammation, fibrosis, and cancer, exemplified by silicosis, asbestosis, and mesothelioma that are progressive and have high mortality rates. Notwithstanding, the role of immune responses in the pathogenesis of particulate-induced diseases has gained increasing attention. A plethora of studies have shown that particulates activate various immune cells to promote physiological responses to particulate deposition and, under pathological conditions, development of fibrosis, malignancy, and autoimmunity. The past two decades have also witnessed rapid advancement of nanotechnology and commercialization of nanomaterials, raising concerns on their possible adverse immune effects in exposed individuals. Understanding the interactions between particulates and immune functions has emerged as a new frontier for researchers in immunology, toxicology, and nanoscience. This Research Topic discusses recent trends in particle immunotoxicology with focus on pathologic immune effects of particulates and mechanisms mediating particle-immune interactions. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Hypersensitivity Immune System Neoplasms Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Airborne Fibers Airborne Particles Allergies Allergy Author Keywords: Particle Autoimmunity Immune Response Immune System Immunology Inflammation Particle Immunotoxicity Inhalation Malignancy Nanomaterials Nanomedicine Nanoparticle Nanoparticles Nanotechnology Particulates

  More +
• ISSN:
  1664-3224
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; OSHA Region 3 ; OSHA Region 8 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• NIOSHTIC Number:
  nn:20062489
• Citation:
  Front Immunol 2021 Mar; 12:665810
• Contact Point Address:
  Qiang Ma, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States
• Email:
  qam1@cdc.gov
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Construction
• Peer Reviewed:
  False
• Source Full Name:
  Frontiers in Immunology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d51bf7c16da92e402d16165f0d34d1a6d1a0ff767e2847d8996fa163c5595b1f98771c589ddb720d06104ab508f356697941fb93d9c286bdcbba36914ddd4c03
• Download URL:
  https://stacks.cdc.gov/view/cdc/225724/cdc_225724_DS1.pdf
• File Type:
  [PDF - 138.60 KB ]