Exercise Interventions Preserve Hippocampal Volume: A Meta-Analysis

Details

• Personal Author:
  Erickson KI ; Foust JE ; Fraundorf SH ; Kang C ; Leckie RL ; Peven JC ; Stillman CM ; Waiwood AM ; Wilckens KA
• Description:
  Hippocampal volume is a marker of brain health and is reduced with aging and neurological disease. Exercise may be effective at increasing and preserving hippocampal volume, potentially serving as a treatment for conditions associated with hippocampal atrophy (e.g., dementia). This meta-analysis aimed to identify whether exercise training has a positive effect on hippocampal volume and how population characteristics and exercise parameters moderate this effect. Studies met the following criteria: (a) controlled trials; (b) interventions of physical exercise; (c) included at least one time-point of hippocampal volume data before the intervention and one after; (d) assessed hippocampal volume using either manual or automated segmentation algorithms. Animal studies, voxel-based morphometry analyses, and multi-modal interventions (e.g., cognitive training or meditation) were excluded. The primary analysis in n = 23 interventions from 22 published studies revealed a significant positive effect of exercise on total hippocampal volume. The overall effect was significant in older samples (65 years of age or older) and in interventions that lasted over 24 weeks and had less than 150 min per week of exercise. These findings suggest that moderate amounts of exercise for interventions greater than 6 months have a positive effect on hippocampal volume including in older populations vulnerable to hippocampal atrophy. [Description provided by NIOSH]
• Subjects:
  Aging Occupational Health Safety
• Keywords:
  Author Keywords: Aging Brain Function Brain Matter Exercise Hippocampus Intervention Effectiveness Magnetic Resonance Imaging Neurological System Physical Activity Physical Exercise
• ISSN:
  1050-9631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 3 ; OSHA Region 4 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  335-347
• Volume:
  31
• Issue:
  3
• NIOSHTIC Number:
  nn:20062465
• Citation:
  Hippocampus 2021 Mar; 31(3):335-347
• Contact Point Address:
  Kristine A. Wilckens, Assistant Professor, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O'Hara Street E-1124, Pittsburgh, PA 15213
• Email:
  wilckenska@upmc.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  Sunshine Education and Research Center, University of South Florida
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Hippocampus
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e737e37f807e0c5898f2142c335db65364a1c9192aa2d245854751b0aa0dcc0c11e297a4538034ccd2103bd5fe12262e51b86b7274a6efede5c9c94b6266a60f
• Download URL:
  https://stacks.cdc.gov/view/cdc/225710/cdc_225710_DS1.pdf
• File Type:
  [PDF - 2.12 MB ]