Single-Cell Transcriptomics Analysis of Mild Cognitive Impairment in World Trade Center Disaster Responders

Details

• Personal Author:
  Bromet E ; Che C ; Clouston S ; Gandy S ; Kotov R ; Kuan P-F ; Luft BJ ; Yang X
• Description:
  Introduction: Recent research has found that World Trade Center (WTC) responders in their mid-50s have an elevated prevalence of mild cognitive impairment (MCI) that is associated with neural degeneration and subcortical thinning. This article extends our understanding of the molecular complexity of MCI through gene expression profiling of blood. Methods: The transcriptomics of 40 male WTC responders were profiled across two cohorts (discovery: nine MCI and nine controls; replication: 11 MCI and 11 controls) using CITE-Seq at single-cell resolution in blood. Results: Comparing the transcriptomic signatures across seven major cell subpopulations, the largest differences were observed in monocytes in which 226 genes were differentially expressed. Pathway analysis on the genes unique to monocytes identified processes associated with cerebral immune response. Discussion: Our findings suggested monocytes may constitute a key cell type to target in blood-based biomarker studies for early detection of risk of MCI and development of new interventions. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Emergency Responders Men Nervous System Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: CITE-Seq Cognitive Function Disaster Response Emergency Responders First Responders Gene Expression Humans Mild Cognitive Impairment Molecular Biology World Trade Center WTC

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• ISSN:
  2352-8729
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  1
• NIOSHTIC Number:
  nn:20062351
• Citation:
  Alzheimers Dement Diagn Assess Dis Monit 2021 Feb; 13(1):e12154
• Contact Point Address:
  Benjamin J. Luft, Pellegrino Professor of Medicine & Director,WTC Program, State University of New York at Stony Brook, Department of Medicine, SUNY at Stony Brook, Nicolls Road, HSC T-16, Room 082A, Stony Brook, NY 11794-8166
• Email:
  Benjamin.luft@stonybrookmedicine.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d593d22e3d58fd02e687f25fbb887e5df6fe0a4c40d1ddfbe352db973b5df1f9d98cfc8fc2c10023ac8657afc01851d637b5eccffaa287f44ad034d977d20e4b
• Download URL:
  https://stacks.cdc.gov/view/cdc/225618/cdc_225618_DS1.pdf
• File Type:
  [PDF - 497.04 KB ]