Exposure to Air Pollution in Critical Prenatal Time Windows and IgE Levels in Newborns

Details

• Personal Author:
  Ashwood P ; Dostal M ; Frost JD ; Ghosh R ; Herr CEW ; Hertz-Picciotto I ; Joad JP ; Lipsett M ; Pinkerton KE ; Skokanova V ; Sram R ; Yap P-S
• Description:
  The objective of this study was to analyze the mechanisms by which exposure to ambient air pollutants influences respiratory health may include altered prenatal immune development. To analyze associations between elevated cord serum Immunoglobulin E (IgE) levels and maternal air pollution exposure during each month of gestation. Total cord serum IgE was determined by the CAP system and mothers' total IgE levels by nephelometry for 459 births in the Czech Republic from May 1994 to mid-January 1997. Concentrations of polycyclic aromatic hydrocarbons (PAHs) and particulate matter <2.5 microns in diameter (PM2.5) were measured in ambient air, and arithmetic means were calculated for each gestational month. Log binomial regression models were used to estimate prevalence ratios (PR) for elevated cord serum IgE (>/=0.9 IU/ml) adjusting for district of residence, year of birth, and in further models, for maternal IgE (a surrogate for atopy) and gestational season. Heterogeneity by maternal atopy status was evaluated for associations of air pollution and of cigarette smoke. In adjusted models, PAH and PM2.5 exposures in the second month of gestation were each associated with a lower prevalence of elevated cord serum IgE. For an average increase of 100 ng/m3 of PAHs, the PR was 0.69 (95% confidence interval (CI): 0.50, 0.95); for 25 microg/m3 increase in PM2.5, the PR was 0.77 (95% CI: 0.55, 1.07). Conversely, exposures later in gestation were associated with a higher prevalence of elevated cord IgE: in the fifth month, the PR for PAH exposure was 1.64 (95% CI: 1.29, 2.08), while for PM2.5 in the sixth month, it was 1.66 (95% CI: 1.30, 2.13). In analyses stratified by maternal atopy, air pollutants were associated with altered cord serum IgE only among neonates with non-atopic mothers. Similarly, an association of cigarette smoke with elevated cord serum IgE was found only in non-atopic mothers. PAHs and PM2.5, constituents of both ambient air pollution and cigarette smoke, appear to influence fetal immune development, particularly among infants whose mothers are not atopic. [Description provided by NIOSH]
• Subjects:
  Air Pollution Hypersensitivity Immune System Occupational Health Particulate Matter Pregnancy Safety
• Keywords:
  Air Pollution Allergies Atopy Author Keywords: Immunoglobulin Critical Window Developmental Immunology Immune Reaction Immunoglobulins PAH Particulates PM2.5 Polycyclic Aromatic Hydrocarbon Polynuclear Aromatic Hydrocarbons Prenatal Exposure Smoking And Cord Serum

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• ISSN:
  0905-6157
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  75-84
• Volume:
  22
• Issue:
  1
• NIOSHTIC Number:
  nn:20062113
• Citation:
  Pediatr Allergy Immunol 2011 Feb; 22(1)(Pt I):75-84
• Contact Point Address:
  Irva Hertz-Picciotto, PhD, Professor, Department of Public Health Sciences, Division of Epidemiology, MS1C, University of California; Davis, Davis, CA 95616, USA
• Email:
  ihp@ucdavis.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Part Number:
  I
• Start Date:
  20010930
• Source Full Name:
  Pediatric Allergy and Immunology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:094c562599f80cc4d7e21f44724f1eded83e6bfb36fc1ccbd34ab5f445e3492bc68e051cbc7722acbf3b91326c18ec509feed745c4a6d895e7eb7aa44c461be5
• Download URL:
  https://stacks.cdc.gov/view/cdc/225425/cdc_225425_DS1.pdf
• File Type:
  [PDF - 303.35 KB ]