Time-varying exposure to ozone and risk of stillbirth in a nonattainment urban region.

Details

• Personal Author:
  Chan W ; Han I ; Rammah A ; Symanski, Elaine ; Whitworth KW
• Description:
  In a racially and ethnically diverse urban area (Harris County, Texas) with historic nonattainment O3 levels, we obtained birth and fetal death records from 2008-2013 and estimated maternal residential O3 concentrations from conception until delivery using inverse-distance interpolation from the local air monitoring network. We examined multipollutant models (with fine particulate matter and nitrogen dioxide) and effect measure modification by race/ethnicity and length of gestation. We found a 9% (95% confidence interval (CI): 1, 18) increased stillbirth risk associated with a 3.6-parts-per-billion increase in O3 exposure. The risk was higher among women with pregnancies of <37 gestational weeks (hazard ratio (HR) = 1.13, 95% CI: 1.04, 1.23) compared with women with pregnancies of longer gestation (HR = 1.05, 95% CI: 0.87, 1.27) and among Hispanic women (HR = 1.14, 95% CI: 1.02, 1.27). We also conducted a case-crossover analysis and detected no associations with short-term exposure. To our knowledge, this study is the first to use time-to-event analyses to examine stillbirth risk associated with time-varying prenatal ozone (O3) exposure over pregnancy. Our findings indicate that maternal O3 exposure over pregnancy is associated with stillbirth risk and that Hispanic women and women with shorter pregnancies might be at particular risk. [Description provided by NIOSH]
• Subjects:
  Air Pollution Mortality Occupational Health Ozone Particulate Matter Pregnancy Race Factors Safety Women
• Keywords:
  Author Keywords: Air Pollution; Ozone; Stillbirth Particulates; Particle Size; Air Pollution; Ozone; Women; Pregnancy; Racial Factors; Prenatal Exposure; Mortality Data;
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  188
• Issue:
  7
• NIOSHTIC Number:
  nn:20064823
• Citation:
  Am J Epidemiol 2019 Jul; 188(7):1288-1295
• Contact Point Address:
  Dr. Elaine Symanski, Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Herman Pressler Street, Suite W-1030, Houston, TX 77030
• Email:
  elaine.symanski@uth.tmc.edu
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0c416e9ad1e4e169d40f5601a9fa7759344aa9a6660154e801e5c6c302b578e53eb8bed9b0814af76f6ba9b44009002d4e63b350e504318aba12c832fa55765c
• Download URL:
  https://stacks.cdc.gov/view/cdc/249248/cdc_249248_DS1.pdf
• File Type:
  [PDF - 239.86 KB ]