Aerosolization System for Experimental Inhalation Studies of Carbon-Based Nanomaterials

Details

• Personal Author:
  Evans JE ; Guo T ; Madl AK ; Masiel D ; Pinkerton KE ; Qu Y ; Teague SV
• Description:
  Assessing the human health risks associated with engineered nanomaterials is challenging because of the wide range of plausible exposure scenarios. While exposure to nanomaterials may occur through a number of pathways, inhalation is likely one of the most significant potential routes of exposure in industrial settings. An aerosolization system was developed to administer carbon nanomaterials from a dry bulk medium into airborne particles for delivery into a nose-only inhalation system. Utilization of a cannula-based feed system, diamond-coated wheel, aerosolization chamber, and krypton-85 source allows for delivery of otherwise difficult to produce respirable-sized particles. The particle size distribution (aerodynamic and actual) and morphology were characterized for different aerosolized carbon-based nanomaterials (e.g., single-walled carbon nanotubes and ultrafine carbon black). Airborne particles represented a range of size and morphological characteristics, all of which were agglomerated particles spanning in actual size from the nanosize range (<0.1 microm) to sizes greater than 5 and 10 microm for the particle's largest dimension. At a mass concentration of 1000 microg/m3, the size distribution as measured by the inertial impactor ranged from 1.3 to 1.7 microm with a sg between 1.2 and 1.4 for all nanomaterial types. Because the aerodynamic size distribution is similar across different particle types, this system offers an opportunity to explore mechanisms by which different nanomaterial physicochemical characteristics impart different health effects while theoretically maintaining comparable deposition patterns in the lungs. This system utilizes relatively small amounts of dry material (<0.05 g/h), which may be beneficial when working with limited quantity or costly nanomaterials. [Description provided by NIOSH]
• Subjects:
  Aerosols Lung Manufacturing And Industrial Facilities Occupational Health Respiratory System Safety
• Keywords:
  Aerosol Particles Carbon Black Carbon Nanotubes CNT Industrial Environment Inhalation Nanomaterials Particle Aerodynamics
• ISSN:
  0278-6826
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  94-107
• Volume:
  46
• Issue:
  1
• NIOSHTIC Number:
  nn:20062111
• Citation:
  Aerosol Sci Technol 2012 Jan; 46(1):94-107
• Contact Point Address:
  Amy K. Madl, Center for Health and the Environment, University of California, One Shields Avenue, Davis, California 95616, USA
• Email:
  akmadl@ucdavis.edu
• CAS Registry Number:
  Carbon black (CAS RN 1333-86-4) ; Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Aerosol Science and Technology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7512b048f298dc3a3ab31a23079f369570c016d4f8a57e35c7e4ab9db4b6325d39885477c4f67cfe9b2cc186d41777f9581aac2ee8e6f04bff029bffbc246e73
• Download URL:
  https://stacks.cdc.gov/view/cdc/225423/cdc_225423_DS1.pdf
• File Type:
  [PDF - 1.35 MB ]