Pesticides and Hepatotoxicity

Details

• Personal Author:
  Hodgson E ; Meyer SA
• Description:
  Pesticides are ubiquitous contaminants of the human environment and, as such, not only interact with hepatic enzymes as substrates, inhibitors, activators, and inducers but are also involved as the causative agents of numerous toxic end points. While the exposure of the general public to pesticides and their metabolites is usually low, exposures are of concern in occupational and other settings. Furthermore, interactions between pesticides and other xenobiotics are known to occur, frequently through the generation of reactive intermediates. Such reactive intermediates may exert their effects in the liver itself or may bring about toxicity in other tissues. The bioprocessing of pesticides by liver enzymes is first considered, including interactions with other xenobiotics or between pesticides and endogenous metabolites brought about by inhibition, induction, and/or activation of xenobiotic-metabolizing enzymes. The role of pesticides as hepatotoxicants, including both noncarcinogenic and carcinogenic end points and the effect of pesticides in modifying the toxicity of other nonpesticidal toxicants, is also considered. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Insecticides Occupational Health Safety Toxicology
• Keywords:
  Biological Effects Hepatocytes Humans Liver Cells Metabolic Effects Metabolism Pesticides And Agricultural Chemicals Xenobiotics
• ISBN:
  9780080468846
• Publisher:
  John Wiley & Sons, Inc
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Book
• Place as Subject:
  Louisiana ; North Carolina ; OSHA Region 4 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  475-500
• Volume:
  9
• NIOSHTIC Number:
  nn:20062095
• Citation:
  Comprehensive toxicology, 2nd edition. McQueen CA, ed. Oxford, UK: Elsevier, 2010 Jan; 9:475-500
• Editor(s):
  McQueen CA
• Federal Fiscal Year:
  2010
• Performing Organization:
  East Carolina University
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Comprehensive toxicology, 2nd edition
• End Date:
  20080929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:917bee26ef68af205be6de0023ec10529b1e83d5b6a61ec57d1c5562a95e06ba7017a4cace20e6014aadd9c06f496c46c413c639e0967aea356f7efbbde3745c
• Download URL:
  https://stacks.cdc.gov/view/cdc/225408/cdc_225408_DS1.pdf
• File Type:
  [PDF - 763.62 KB ]