Arterial Stiffness and Occupational Exposure to Fine Particulate Matter

Details

• Personal Author:
  Cavallari J ; Christiani D ; Eisen E ; Fang S ; Mittleman M
• Description:
  Exposure to particulate matter is associated with adverse cardiovascular events, but the mechanisms remain unclear. We investigated the association between short-term exposure to occupational fine particulate matter (PM2.5) and arterial stiffness, a component of vascular function. A short-term prospective study of 26 male boilermaker construction workers was conducted. The augmentation index (AIx, %), a measure of arterial stiffness, was obtained pre-shift (baseline), post-shift, and the morning after a welding day and a non-exposed control day. Exposure was measured as binary (weld) and as continuous (work-shift PM2.5, mg/m3 ). Smoking-adjusted linear regression models evaluated the effects of welding and PM2.5 on change in AIx. On a control day, AIx decreased baseline to post-shift (p < 0.001) and increased post-shift to next morning (p < 0.001). Both changes were blunted after welding exposure. Welding during the workshift and the day prior to baseline was associated with a significantly blunted cross-shift change (p = 0.03). A similar association was found for welding in relation to AIx change from post-shift to next morning. Using log PM2.5, we observed a positive linear relationship with baseline to post-shift change (b = 1.12; 95% CI: -0.33, 2.57) and an inverse linear relationship with post-shift to next morning change (b = -2.75; 95% CI: -4.61, -0.89). The data suggest that subsequent to exposure there is attenuation of the circadian afternoon decrease in AIx and delayed recovery back to baseline AIx the following morning. In compromised individuals, these acute vascular changes may be involved in particulate-related cardiovascular events. Health consequences in young healthy males require further research. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Circadian Rhythm Construction Industry Environmental Exposure Men Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Smokers Welding

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• Keywords:
  Cardiovascular System Cardiovascular System Disorders Circadian Rhythms Construction Workers Exposure Levels Health Effects Humans Models Particulates Risk Factors Smoking

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  165
• NIOSHTIC Number:
  nn:20062084
• Citation:
  Am J Epidemiol 2007 Jun; 165 (Suppl 11):S133
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• Supplement:
  11
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:732db3817055d4fd928543b29fec8d3e2660ebae7b31854cb63581cb6e1af498e37025dc3ed1b9e767dca74d07abc9d6075008f060c49404213bf93fe2b5aef3
• Download URL:
  https://stacks.cdc.gov/view/cdc/225401/cdc_225401_DS1.pdf
• File Type:
  [PDF - 68.79 KB ]