Short-term metal particulate exposures decrease cardiac acceleration and deceleration capacities in welders: a repeated-measures panel study

Details

• Personal Author:
  Cavallari JM ; Christiani, David C. ; Fang SC ; Lin X ; Lu C ; Mittleman MA ; Umukoro PE
• Description:
  Objective: Acceleration (AC) and deceleration (DC) capacities measure heart rate variability during speeding up and slowing down of the heart, respectively. We investigated associations between AC and DC with occupational short-term metal PM2.5 exposures. Methods: A panel of 48 male welders had particulate matter less than 2.5 microns in diameter (PM2.5) exposure measurements over 4-6 h repeated over 5 sampling periods between January 2010 and June 2012. We simultaneously obtained continuous recordings of digital ECG using a Holter monitor. We analysed ECG data in the time domain to obtain hourly AC and DC. Linear mixed models were used to assess the associations between hourly PM2.5 exposure and each of hourly AC and DC, controlling for age, smoking status, active smoking, exposure to secondhand smoke, season/ time of day when ECG reading was obtained and baseline AC or DC. We also ran lagged exposure response models for each successive hour up to 3 h after onset of exposure. Results: Mean (SD) shift PM2.5 exposure during welding was 0.47 (0.43) mg/m3. Significant exposure-response associations were found for AC and DC with increased PM2.5 exposure. In our adjusted models without any lag between exposure and response, a 1 mg/m3 increase of PM2.5 was associated with a decrease of 1.46 (95% CI 1.00 to 1.92) ms in AC and a decrease of 1.00 (95% CI 0.53 to 1.46) ms in DC. The effect of PM2.5 on AC and DC was maximal immediately postexposure and lasted 1 h following exposure. Conclusions: There are short-term effects of metal particulates on AC and DC. [Description provided by NIOSH]
• Subjects:
  Cardiovascular System Environmental Exposure Environmental Pollution Men Metals Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Welding

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• Keywords:
  Cardiac-function Environmental-exposure Environmental-hazards Exposure-levels Hazards Heart Heart-rate Humans Metal-compounds Metallic-compounds Models Particulates Risk-factors Statistical-analysis Welders Welding-industry

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• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  91-96
• Volume:
  73
• Issue:
  2
• NIOSHTIC Number:
  nn:20047099
• Citation:
  Occup Environ Med 2016 Feb; 73(2):91-96
• Contact Point Address:
  Dr David C Christiani, Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA 02115 USA
• Email:
  dchris@hsph.harvard.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dae06dc67d0ee2a5f82c5944a9b3b21a3c2a4b969b0c536681b75ce03dbb8bb6104f84e13623f432d97e1b5f0775778078097999d4e327199febd428f0e3533b
• Download URL:
  https://stacks.cdc.gov/view/cdc/202295/cdc_202295_DS1.pdf
• File Type:
  [PDF - 360.94 KB ]