Metabolic and Inflammatory Links to Depression in Youth With Diabetes

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Hood, Korey K. ; Lawrence, Jean M. ; Anderson, Andrea ; Bell, Ronny ; Dabelea, Dana ; Daniels, Stephen ; Rodriguez, Beatriz ; Dolan, Lawrence M.
• Corporate Authors:
  for the SEARCH for Diabetes in Youth Study Group
• Description:
  OBJECTIVE
  
  Youth with diabetes are at increased risk for depression. The objectives of this study were to provide preliminary evidence that this at-risk status for depression is associated with metabolic and inflammatory markers and to inform future, more stringent examinations of the directionality of these associations.
  
  RESEARCH DESIGN AND METHODS
  
  Data from SEARCH for Diabetes in Youth (SEARCH), an observational study of U.S. children diagnosed with diabetes at <20 years of age, were used for these analyses. SEARCH participants were drawn from four geographically defined populations in Ohio, Washington, South Carolina, and Colorado; health plan enrollees in Hawaii and California; and Indian Health Service beneficiaries from four Native American populations. Participants were 2,359 youth with diabetes from the 2001 prevalent and 2002–2004 incident SEARCH cohorts. Depression was measured with the Center for Epidemiologic Studies Depression scale. Eight metabolic and inflammatory markers were measured: adiponectin, leptin, C-reactive protein, serum amyloid A, apolipoprotein B (apoB), lipoprotein A, interleukin-6, and LDL.
  
  RESULTS
  
  Six of eight markers were significantly (P < 0.006) associated with depression in youth with diabetes in bivariate analyses. In general, higher levels of depression were associated with indicators of worse metabolic or inflammatory functioning. In regression models stratified by diabetes type and accounting for demographic and clinical characteristics, only higher levels of apoB remained associated with higher levels of depression in youth with type 1 diabetes.
  
  CONCLUSIONS
  
  These data suggest that depression reported by youth with diabetes is partially associated with metabolic abnormalities and systemic inflammation.
  
  
• Subjects:
  Adiponectin Adolescent Apolipoproteins B C-Reactive Protein Child Depression Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Female Humans Inflammation Interleukin-6 Leptin Male Original Research

  More +
• Source:
  Diabetes Care. 2012; 35(12):2443-2446.
• Pubmed ID:
  23033243
• Pubmed Central ID:
  PMC3507554
• Document Type:
  Journal Article
• Funding:
  1U18-DP-002709/DP/NCCDPHP CDC HHS/United States ; 1UL1-RR-026314-01/RR/NCRR NIH HHS/United States ; DP-05-069/DP/NCCDPHP CDC HHS/United States ; DP-10-001/DP/NCCDPHP CDC HHS/United States ; M01-RR-00037/RR/NCRR NIH HHS/United States ; M01-RR-00069/RR/NCRR NIH HHS/United States ; P30-DK-57516/DK/NIDDK NIH HHS/United States ; U01-DP-000244/DP/NCCDPHP CDC HHS/United States ; U01-DP-000245/DP/NCCDPHP CDC HHS/United States ; U01-DP-000246/DP/NCCDPHP CDC HHS/United States ; U01-DP-000247/DP/NCCDPHP CDC HHS/United States ; U01-DP-000248/DP/NCCDPHP CDC HHS/United States ; U01-DP-000250/DP/NCCDPHP CDC HHS/United States ; U01-DP-000254/DP/NCCDPHP CDC HHS/United States ; U18-DP-000247-06A1/DP/NCCDPHP CDC HHS/United States ; U18-DP-002708-01/DP/NCCDPHP CDC HHS/United States ; U18-DP-002710-01/DP/NCCDPHP CDC HHS/United States ; U18-DP-002714/DP/NCCDPHP CDC HHS/United States ; U48/CCU419249/PHS HHS/United States ; U48/CCU519239/PHS HHS/United States ; U48/CCU819241-3/PHS HHS/United States ; U48/CCU919219/PHS HHS/United States ; U58/CCU019235-4/PHS HHS/United States ; U58/CCU919256/PHS HHS/United States ; UL1 RR029882/RR/NCRR NIH HHS/United States ; UL1 TR000062/TR/NCATS NIH HHS/United States ; UL1 TR000077/TR/NCATS NIH HHS/United States ; UL1-RR-029882/RR/NCRR NIH HHS/United States
• Volume:
  35
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0c80a641a175255e2a6304f58e357ba34934dca323e63c237a1bffa0626fdacb
• Download URL:
  https://stacks.cdc.gov/view/cdc/22537/cdc_22537_DS1.pdf
• File Type:
  [PDF - 89.67 KB ]