Innovative Application of Fluoro Tagging to Trace Airborne Particulate and Gas-Phase Polybrominated Diphenyl Ether Exposures

Details

• Personal Author:
  Adamcakova-Dodd A ; Klösener J ; Luthe G ; Peters TM ; Robertson LW ; Teesch LM ; Thorne PS
• Description:
  Polybrominated diphenyl ethers (PBDEs) are flame retardants applied as coatings to many consumer products, including household items. PBDEs are released and produce airborne vapors and dusts. Inhalation of particle-phase and/or gas-phase PBDEs is therefore a major route of exposure. In an attempt to mimic realistic airborne exposures, actual uptake, and deposition of particles and vapors, we prepared and characterized particles for future animal exposure studies. To trace the particles in environmental and biological systems, we employed fluoro tagging. We synthesized, characterized, and employed three PBDE congeners, 35, 47, and 99, and five fluoro-substituted PBDEs (F-PBDEs), 17-F5', 25-F5', 28-F3', 35-F5', 47-F3, and 99-F3', for this study. The PBDE congeners were selected because they are commonly found in house dust. For that reason, we coated spherical silica particles of 3 microm and C18 endcapped silica as representative and inert support materials, with 20, 30, and 40% PBDEs. We determined the particle size distributions by aerodynamic particle size spectrometry and the morphology by scanning electron microscopy. The suitability of the fluoro-tagged tracers to mimic their corresponding parent PBDEs was investigated by extraction studies from spiked blood serum. Our study is of fundamental importance to the development of xenobiotic tracers for monitoring routes of human exposure to PBDEs and understanding uptake of PBDEs from particles and vapors. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Environmental Monitoring Occupational Health Particulate Matter Respiratory System Safety Silicon Dioxide Solvents Spectrum Analysis
• Keywords:
  Airborne Dusts Airborne Particles Biological Systems Coatings Environmental Monitoring Exposure Assessment Flame Retardants Inhalation Morphology Particle Aerodynamics Particle Size Particle Size Analysis Polybrominated Diphenyl Ethers Scanning Electron Microscopy Silica Spectrographic Analysis Vapors Xenobiotics

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• ISSN:
  0893-228X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  179--186
• Volume:
  22
• Issue:
  1
• NIOSHTIC Number:
  nn:20061911
• Citation:
  Chem Res Toxicol 2009 Jan; 22(1):179-186
• Contact Point Address:
  Gregor Luthe, Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, Iowa City, Iowa 52242
• Email:
  gregor-luthe@uiowa.edu
• CAS Registry Number:
  Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Chemical Research in Toxicology
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:910d9903efdfb1e659c224d20660d73c409f57b864a48af792243d0cdabcd7f08df138baf0be9c913e8985caf24fd2e44e9b324f4812b48e8cb581562fcabe0d
• Download URL:
  https://stacks.cdc.gov/view/cdc/225256/cdc_225256_DS1.pdf
• File Type:
  [PDF - 3.71 MB ]