Dietary Phenotype and Advanced Glycation End-Products Predict WTC-Obstructive Airways Disease: A Longitudinal Observational Study

Details

• Personal Author:
  Colbeth H ; Crowley G ; Halpren A ; Kwon S ; Lam R ; Liu M ; Nolan A ; Prezant DJ ; Riggs J ; Schwartz T ; Sunseri M ; Zeig-Owens R
• Description:
  Background: Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, physical activity, and dietary habits) of the Fire Department of New York (FDNY) WTC-Health Program (WTC-HP) cohort and (2) quantify the association of dietary quality and its advanced glycation end product (AGE) content with the development of WTC-OAD. Methods: WTC-OAD, defined as developing WTC-Lung Injury (WTC-LI; FEV1 < LLN) and/or airway hyperreactivity (AHR; positive methacholine and/or positive bronchodilator response). Rapid Eating and Activity Assessment for Participants-Short Version (REAP-S) deployed on 3/1/2018 in the WTC-HP annual monitoring assessment. Clinical and REAP-S data of consented subjects was extracted (7/17/2019). Diet quality [low-(15-19), moderate-(20-29), and high-(30-39)] and AGE content per REAP-S questionnaire were assessed for association with WTC-OAD. Regression models adjusted for smoking, hyperglycemia, hypertension, age on 9/11, WTC-exposure, BMI, and job description. Results: N = 9508 completed the annual questionnaire, while N = 4015 completed REAP-S and had spirometry. WTC-OAD developed in N = 921, while N = 3094 never developed WTC-OAD. Low- and moderate-dietary quality, eating more (processed meats, fried foods, sugary drinks), fewer (vegetables, whole-grains),and having a diet abundant in AGEs were significantly associated with WTC-OAD. Smoking was not a significant risk factor of WTC-OAD. Conclusions: REAP-S was successfully implemented in the FDNY WTC-HP monitoring questionnaire and produced valuable dietary phenotyping. Our observational study has identified low dietary quality and AGE abundant dietary habits as risk factors for pulmonary disease in the context of WTC-exposure. Dietary phenotyping, not only focuses our metabolomic/biomarker profiling but also further informs future dietary interventions that may positively impact particulate matter associated lung disease. [Description provided by NIOSH]
• Subjects:
  Age Factors Biomarkers Cardiovascular Diseases Cardiovascular System Diet Energy Metabolism Environmental Exposure Lung Lung Diseases Methacholine Compounds Occupational Health Particulate Matter Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Smokers Surveys And Questionnaires

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• Keywords:
  Age Factors Airway Obstruction Author Keywords: Diet BMI Body Mass Index Diseases Exposure Levels Food Foodstuff Hypertension Injuries Lung Disease Metabolic Syndrome Metabolism Methacholines Models Monitoring Systems Nutrition Particulates Physical Exercise Pulmonary System Disorders Questionnaires Respiratory System Disorders Risk Factors Smoking Spirometry Statistical Analysis World Trade Center WTC

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• ISSN:
  1465-9921
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  19
• Volume:
  22
• NIOSHTIC Number:
  nn:20061867
• Citation:
  Respir Res 2021 Jan; 22:19
• Contact Point Address:
  Anna Nolan, Department of Medicine, Division of Pulmonary, Critical Care and Sleep, New York University, School of Medicine, New Bellevue, 16 S Room 16 (Office), 16N Room 20 (Lab), 462 1st Avenue, New York, NY 10016
• Email:
  anna.nolan@med.nyu.edu
• CAS Registry Number:
  Methacholine (CAS RN 55-92-5)
• Federal Fiscal Year:
  2021
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Respiratory Research
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1cb834d07d592387c58de3c615c9942ae4f1aa7c0fb24354028821dd0a65e9733f6efd5f52bc618115e4123c7c4f2b4ecf7f0ba0defe9d24cad93e5941a05ad1
• Download URL:
  https://stacks.cdc.gov/view/cdc/225223/cdc_225223_DS1.pdf
• File Type:
  [PDF - 2.06 MB ]