Metabolic Syndrome Biomarkers of World Trade Center Airway Hyperreactivity: A 16-Year Prospective Cohort Study

Details

• Personal Author:
  Clementi E ; Crowley G ; Kwon S ; Lam R ; Liu M ; Mikhail M ; Nolan A ; Prezant DJ ; Schwartz TM ; Zeig-Owens R
• Description:
  Airway hyperreactivity (AHR) related to environmental exposure is a significant public health risk worldwide. Similarly, metabolic syndrome (MetSyn), a risk factor for obstructive airway disease (OAD) and systemic inflammation, is a significant contributor to global adverse health. This prospective cohort study followed N = 7486 World Trade Center (WTC)-exposed male firefighters from 11 September 2001 (9/11) until 1 August 2017 and investigated N = 539 with newly developed AHR for clinical biomarkers of MetSyn and compared them to the non-AHR group. Male firefighters with normal lung function and no AHR pre-9/11 who had blood drawn from 9 September 2001- 24 July 2002 were assessed. World Trade Center-Airway Hyperreactivity (WTC-AHR) was defined as either a positive bronchodilator response (BDR) or methacholine challenge test (MCT). The electronic medical record (EMR) was queried for their MetSyn characteristics (lipid profile, body mass index (BMI), glucose), and routine clinical biomarkers (such as complete blood counts). We modeled the association of MetSyn characteristics at the first post-9/11 exam with AHR. Those with AHR were significantly more likely to be older, have higher BMIs, have high intensity exposure, and have MetSyn. Smoking history was not associated with WTC-AHR. Those present on the morning of 9/11 had 224% increased risk of developing AHR, and those who arrived in the afternoon of 9/11 had a 75.9% increased risk. Having >/=3 MetSyn parameters increased the risk of WTC-AHR by 65.4%. Co-existing MetSyn and high WTC exposure are predictive of future AHR and suggest that systemic inflammation may be a contributor. [Description provided by NIOSH]
• Subjects:
  Age Factors Air Pollutants, Occupational Biomarkers Blood Cohort Studies Energy Metabolism Environmental Exposure Environmental Pollution Firefighters Hematologic Tests Lung Lung Diseases Men Methacholine Compounds Occupational Health Particulate Matter Public Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Age Factors Airborne Particulates Airway Hyperreactivity Airway Obstruction Author Keywords: Metabolic Syndrome Blood Samples BMI Body Mass Index Chronic Inflammation Clinical Symptoms Cohort Studies Environmental Contamination Environmental Exposure Exposure Assessment Fire Fighters Lung Disease Lung Function Metabolic Disorders Metabolic Effects Metabolic Study Methacholines Particulates Public Health Pulmonary Function Pulmonary Function Tests Respiratory Diseases Respiratory Health Risk Factors World Trade Center WTC

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  9
• NIOSHTIC Number:
  nn:20055661
• Citation:
  Int J Environ Res Public Health 2019 May; 16(9):1486
• Contact Point Address:
  Anna Nolan, Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA
• Email:
  anna.nolan@med.nyu.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:427f4db88cae471a46ae231b669eb712c171f28e2abf66fe296af38d57e67abbb0d57f214d6f2a6075978d8cacdeab795f899a96643cea83da1b99f54c97ba97
• Download URL:
  https://stacks.cdc.gov/view/cdc/213455/cdc_213455_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]