Parental Occupational Exposures and the Risk of Childhood Sporadic Retinoblastoma: A Report from the Children’s Oncology Group

Details

• Personal Author:
  Bunin GR ; Ganguly A ; Heck JE ; Kennedy N ; Krause N ; Omidakhsh N ; Ritz B ; von Ehrenstein OS
• Description:
  Objectives: We examined associations between parental occupational chemical exposures up to 10 years before conception and the risk of sporadic retinoblastoma among offspring. Methods: In our multicentre study on non-familial retinoblastoma, parents of 187 unilateral and 95 bilateral cases and 155 friend controls were interviewed by telephone. Exposure information was collected retroactively through a detailed occupational questionnaire that asked fathers to report every job held in the 10 years before conception, and mothers 1 month before and during the index pregnancy. An industrial hygienist reviewed all occupational data and assigned an overall exposure score to each job indicating the presence of nine hazardous agents. Results: We estimated elevated ORs for unilateral and bilateral retinoblastoma among offspring of fathers who were exposed to polycyclic aromatic hydrocarbons or paints in the 10 years before conception. However, only for exposure to paints did confidence limits exclude the null for bilateral disease (OR: 8.76, 95% CI: 1.32 to 58.09). Maternal prenatal exposure to at least one of the nine agents was related to increased risk of unilateral disease in their children (OR: 5.25, 95% CI: 1.14 to 24.16). Fathers exposed to at least one of the nine agents and who were >/=30 years of age were at increased risk of having a child diagnosed with bilateral retinoblastoma (OR: 6.59, 95% CI: 1.34 to 32.42). Conclusions: Our results suggest a role for several hazardous occupational exposures in the development of childhood retinoblastoma. [Description provided by NIOSH]
• Subjects:
  Chemistry Epidemiology Eye Neoplasms Occupational Exposure Occupational Health Pregnancy Safety Sense Organs
• Keywords:
  Cancer Rates Chemical Processing Children Eyes Occupational Exposure Occupations Population Based Studies Prenatal Exposure Retinal Disorders Tumors
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  205-211
• Volume:
  75
• Issue:
  3
• NIOSHTIC Number:
  nn:20050547
• Citation:
  Occup Environ Med 2018 Mar; 75(3):205-211
• Contact Point Address:
  Dr Julia E Heck, Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095-1772, USA
• Email:
  jeheck@ucla.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9d3c0dca89b9f9c32482bb1d18e3bc83997db2457d4e903ba0cfb9a8d28e85bf2d74aebad1c9020b9fd165bb6864ad5a486cbbcc4a4854752851ff8cc3cb1c9e
• Download URL:
  https://stacks.cdc.gov/view/cdc/210850/cdc_210850_DS1.pdf
• File Type:
  [PDF - 241.88 KB ]