Dual Substance Use of Electronic Cigarettes and Alcohol

Details

• Personal Author:
  Wetzel TJ ; Wyatt TA
• Description:
  Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long history of the comorbidity of alcohol and nicotine use, the rising prevalence of ECs raises the question as to their role in the consumption of alcohol. Of the numerous models of ECs available, JUUL is the most popular. This narrative review aims to determine current trends in literature regarding the relationship between EC and alcohol dual use, as well as hypothesize potential pathogenic tissue damage and summarize areas for future study, including second-hand vapor exposure and calling for standardization among studies. In summary, EC users are more likely to participate in hazardous drinking and are at higher risk for alcohol use disorder (AUD). We surmise the pathogenic damage of dual use may exhibit an additive effect, particularly in pathogen clearance from the lungs, increased inflammation and decreased immune response, physical damage to epithelial cells, and exacerbation of chronic obstructive pulmonary disease (COPD)-like illnesses. A better understanding of pathogenic damages is critical to understand the risks placed on dual users when exposed to respiratory pathogens, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [Description provided by NIOSH]
• Subjects:
  Alcoholic Beverages Immune System Nicotine Occupational Health Safety Smokers Solvents
• Keywords:
  Alcohol Alcoholic Beverages Author Keywords: Alcohol Misuse Cigarette Smoke ECIG Ethanol Ethyl Alcohol Immune Reaction Lung Clearance Polysubstance Use Secondhand Smoke Smoking Substance Use Vaping Vapors

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• ISSN:
  1664-042X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• NIOSHTIC Number:
  nn:20061574
• Citation:
  Front Physiol 2020 Nov; 11:593803
• Contact Point Address:
  Tanner J. Wetzel, Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, NE, United States
• Email:
  twyatt@unmc.edu
• CAS Registry Number:
  (-)-Nicotine (CAS RN 54-11-5) ; Ethanol (CAS RN 64-17-5)
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Frontiers in Physiology
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b9045a63612569a069b41d81246bfb35f27a14fa462a9f73aea3e59ef75f3af9b00273df681c2869f5f663620ff0b0aad8b7321e863072d67be49d712b0e273c
• Download URL:
  https://stacks.cdc.gov/view/cdc/225077/cdc_225077_DS1.pdf
• File Type:
  [PDF - 466.50 KB ]