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Analyses of Cancer Incidence and Other Morbidities in Gamma Irradiated B6CF1 Mice



Details

  • Personal Author:
  • Description:
    With increasing medical radiation exposures, it is important to understand how different modes of delivery of ionizing radiation as well as total doses of exposure impact health outcomes. Our lab studied the risks associated with ionizing radiation by analyzing the Northwestern University Radiation Archive for animals (NURA). NURA contains detailed data from a series of 10 individual neutron and gamma irradiation experiments conducted on over 50,000 mice. Rigorous statistical testing on control mice from all Janus experiments enabled us to select studies that could be compared to one another and uncover unexpected differences among the controls as well as experimental animals. For controls, mice sham irradiated with 300 fractions died significantly earlier than those with fewer sham fractions and were excluded from the pooled dataset. Using the integrated dataset of gamma irradiated and control mice, we found that fractionation significantly decreased the death hazard for animals dying of lymphomas, tumors, non-tumors, and unknown causes. Gender differences in frequencies of causes of death were identified irrespective of irradiation and dose fractionation, with female mice being at a greater risk for all causes of death, except for lung tumors. Irradiated and control male mice were at a significantly greater risk for lung tumors, the opposite from observations noted in humans. Additionally, we discovered that lymphoma deaths can occur quickly after exposures to high doses of gamma rays. This study systematically cross-compared outcomes of different modes of fractionation evaluated across different Janus experiments and across a wide span of total doses. It demonstrates that protraction modulated survival and disease status differently based on the total dose, cause of death, and sex of an animal. This novel method for analyzing the Janus datasets will lead to insightful new mechanistic hypotheses and research in the fields of radiation biology and protection. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1932-6203
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    15
  • Issue:
    8
  • NIOSHTIC Number:
    nn:20061455
  • Citation:
    PLoS One 2020 Aug; 15(8):e0231510
  • Contact Point Address:
    Gayle E. Woloschak, Feinberg School of Medicine, Radiation Oncology, Northwestern University, Chicago, IL, United States of America
  • Email:
    g-woloschak@northwestern.edu
  • Federal Fiscal Year:
    2020
  • Performing Organization:
    Northwestern University - Chicago
  • Peer Reviewed:
    True
  • Start Date:
    20130901
  • Source Full Name:
    PLoS One
  • End Date:
    20180831
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:70bac7addb5a764fb34a84f8890d9da56adcf12940c6120402d06e3bfe015ab2c3404930bda4b4fb3000f858ee9b262bea6a486d17a44001df58ed8f5d118e94
  • Download URL:
  • File Type:
    Filetype[PDF - 632.88 KB ]
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