Ultrasonically encoded wavefront shaping for focusing into random media

Details

• Alternative Title:
  Sci Rep
• Personal Author:
  Tay, Jian Wei ; Lai, Puxiang ; Suzuki, Yuta ; Wang, Lihong V.
• Description:
  Phase distortions due to scattering in random media restrict optical focusing beyond one transport mean free path. However, scattering can be compensated for by applying a correction to the illumination wavefront using spatial light modulators. One method of obtaining the wavefront correction is by iterative determination using an optimization algorithm. In the past, obtaining a feedback signal required either direct optical access to the target region, or invasive embedding of molecular probes within the random media. Here, we propose using ultrasonically encoded light as feedback to guide the optimization dynamically and non-invasively. In our proof-of-principle demonstration, diffuse light was refocused to the ultrasound focal zone, with a focus-to-background ratio of more than one order of magnitude after 600 iterations. With further improvements, especially in optimization speed, the proposed method should find broad applications in deep tissue optical imaging and therapy.
• Subjects:
  Feedback Light Optical Imaging Scattering, Radiation Ultrasonics
• Source:
  Sci Rep. 2014; 4.
• Pubmed ID:
  24472822
• Pubmed Central ID:
  PMC3905274
• Document Type:
  Journal Article
• Funding:
  DP1 EB016986/DP/NCCDPHP CDC HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States
• Volume:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1229a446c0820247aa7041386aca922696a640e359e3626f55945e433b0b1f17
• Download URL:
  https://stacks.cdc.gov/view/cdc/22496/cdc_22496_DS1.pdf
• File Type:
  [PDF - 589.39 KB ]