Welding Fume Inhalation Exposure and High-Fat Diet Change Lipid Homeostasis in Rat Liver

Details

• Personal Author:
  Antonini JM ; Boyce GR ; Erdely A ; Kodali V ; McKinney W ; Meighan TG ; Powel MJ ; Roach KA ; Roberts, Jennifer R. ; Shoeb M ; Stone S ; Zeidler-Erdely PC
• Description:
  It is estimated that greater than 1 million workers are exposed to welding fume (WF) by inhalation daily. The potentially toxic metals found in WF are known to cause multiple adverse pulmonary and systemic effects, including cardiovascular disease, and these metals have also been shown to translocate to the liver. This occupational exposure combined with a high fat (HF) Western diet, which has been shown to cause hyperlipidemia and non-alcoholic fatty liver disease (NAFLD), has the potential to cause significant mixed exposure metabolic changes in the liver. The goal of this study was to use matrix assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS) to analyze the spatial distribution and abundance changes of lipid species in Sprague Dawley rat liver maintained on a HF diet combined with WF inhalation. The results of the MALDI-IMS analysis revealed unique hepatic lipid profiles for each treatment group. The HF diet group had significantly increased abundance of triglycerides and phosphatidylinositol lipids, as well as decreased lysophosphatidic lipids and cardiolipin. Ceramide-1-phosphate was found at higher abundance in the regular (REG) diet WF-exposed group which has been shown to regulate the eicosanoid pathway involved in pro-inflammatory response. The results of this study showed that the combined effects of WF inhalation and a HF diet significantly altered the hepatic lipidome. Additionally, pulmonary exposure to WF alone increased lipid markers of inflammation. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cardiovascular Diseases Cardiovascular System Diet Digestive System Digestive System Diseases Hazardous Substances Lipids Liver Lung Diseases Metals Occupational Health Respiratory Tract Diseases Safety Welding Workplace

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• Keywords:
  Author Keywords: Diet Cardiovascular System Disorders Diseases Health Effects Lipid Liver Disease Liver Disorders Mass Spectrometry Msass Spectrometry Pulmonary System Disorders Respiratory System Disorders Toxic Effects Toxic Fumes Toxins Welding Fumes Work Environment Workers

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• ISSN:
  2214-7500
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• NIOSHTIC Number:
  nn:20061291
• Citation:
  Toxicol Rep 2020 Oct; 7:1350-1355
• Contact Point Address:
  Greg R. Boyce, National Institute for Occupational Safety and Health, Morgantown, WV
• Email:
  omu0@cdc.gov
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Reports
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c7da04817d0a5ab4cfde2a51d5657b81cc20132ac897af10f2a66143352f51bb8c718284be481c3aaffd14e43fc1f14735fca9dfd59a62b01a19e21fade021de
• Download URL:
  https://stacks.cdc.gov/view/cdc/224863/cdc_224863_DS1.pdf
• File Type:
  [PDF - 5.27 MB ]