Cigarette Smoking and Malignant Melanoma: Prognostic Implications

Details

• Personal Author:
  Friedman RJ ; Kopf AW ; Levenstein M ; Levine J ; Rigel DS
• Description:
  In a prospective study of 178 patients with malignant melanoma, a subset of 33 patients (18.5%) was identified to be at significantly higher risk for developing metastatic disease based on history of cigarette smoking. Patients in this high-risk group (current smokers with a >15 pack-years of smoking history) had two-year disease-free survival rates of 74.2%, versus 92.3% for the remaining patients (p =0.008). A possible explanation of this phenomenon is that chronic smoking diminishes host defense mechanisms and results in an adverse effect on the biologic behavior of established malignant melanomas. [Description provided by NIOSH]
• Subjects:
  Neoplasms Occupational Health Risk Assessment Risk Factors Safety Skin Skin Diseases Smokers Tobacco Products
• Keywords:
  Cancer Cancer Rates Cigarette Smoking Malignant Neoplasms Risk Factors Skin Cancer
• ISSN:
  0148-0812
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  11
• NIOSHTIC Number:
  nn:20061140
• Citation:
  J Dermatol Surg Oncol 1981 Nov; 7(11):889-891
• Contact Point Address:
  Drs. Rigel and Friedman, Skin and Cancer Unit, New York University Medical Center, 566 First Avenue, New York, NY 10016
• Federal Fiscal Year:
  1982
• Performing Organization:
  New York University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  The Journal of Dermatologic Surgery and Oncology
• End Date:
  19820331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fa66e7fcf9fc732fc0f8e28c47313b6925b0399992e6e0442cf6140cf22029edf7899716dc510811ade5d1e5b79ffb6c92f1bf9fd004d429770fa9dc9c0bc7df
• Download URL:
  https://stacks.cdc.gov/view/cdc/224784/cdc_224784_DS1.pdf
• File Type:
  [PDF - 258.40 KB ]