Cigarette Smoking and Malignant Melanoma: Prognostic Implications

Details

• Personal Author:
  Friedman RJ ; Kopf AW ; Levenstein M ; Levine J ; Rigel DS
• Description:
  In a prospective study of 178 patients with malignant melanoma, a subset of 33 patients (18.5%) was identified to be at significantly higher risk for developing metastatic disease based on history of cigarette smoking. Patients in this high-risk group (current smokers with a >15 pack-years of smoking history) had two-year disease-free survival rates of 74.2%, versus 92.3% for the remaining patients (p =0.008). A possible explanation of this phenomenon is that chronic smoking diminishes host defense mechanisms and results in an adverse effect on the biologic behavior of established malignant melanomas. Description provided by NIOSH
• Subjects:
  • Neoplasms
  • Occupational Health
  • Risk Assessment
  • Risk Factors
  • Safety
  • Skin
  • Skin Diseases
  • Smokers
  • Tobacco Products
• Keywords:
  • Cancer
  • Skin cancer
  • Risk factors
  • Malignant neoplasms
  • Cigarette smoking
  • Cancer rates
• ISSN:
  0148-0812
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  11
• NIOSHTIC Number:
  nn:20061140
• Citation:
  J Dermatol Surg Oncol 1981 Nov; 7(11):889-891
• Contact Point Address:
  Drs. Rigel and Friedman, Skin and Cancer Unit, New York University Medical Center, 566 First Avenue, New York, NY 10016
• Federal Fiscal Year:
  1982
• Performing Organization:
  New York University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19790401
• Source Full Name:
  The Journal of Dermatologic Surgery and Oncology
• End Date:
  19820331
• Download URL:
  https://stacks.cdc.gov/view/cdc/224784/cdc_224784_DS1.pdf
• File Type:
  [PDF - 258.40 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fa66e7fcf9fc732fc0f8e28c47313b6925b0399992e6e0442cf6140cf22029edf7899716dc510811ade5d1e5b79ffb6c92f1bf9fd004d429770fa9dc9c0bc7df