Accelerated Loss of FEV- in Polyurethane Production Workers: A Four-Year Prospective Study

Details

• Personal Author:
  Main DM ; Musk AW ; Pagnotto LD ; Wegman, David H.
• Description:
  A four-year longitudinal study of ventilatory function in polyurethane-foam production workers exposed to toluene diisocyanate (TDI) revealed a dose-response relationship between average exposure to TDI and change in forced expiratory volume per second (FEV-1). Workers with mean exposure in excess of 0.0035 ppm showed a greater rate of decline of FEV-1 over the four-year period than that expected from aging. Factors other than TDI exposure (sex, smoking history, history of atopy) do not account for the loss. The current threshold limit value (TLV) for exposure to TDI in industry (0.02 ppm) does not protect workers from accelerated impairment of ventilatory capacity. [Description provided by NIOSH]
• Subjects:
  Isocyanates Occupational Exposure Occupational Health Respiratory System Safety Toluene
• Keywords:
  Author Keywords: TDI Diisocyanates Dose Response Forced Expiratory Volume Longitudinal Study Occupational Exposure Polyurethane Foams Prospective Study Respiratory Function Threshold Limit Values TLV

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Massachusetts ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  209-215
• Volume:
  3
• Issue:
  2
• NIOSHTIC Number:
  nn:20061138
• Citation:
  Am J Ind Med 1982 Feb; 3(2):209-215
• Contact Point Address:
  Dr. David H. Wegman, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19770930
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  19940630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fb4bfda1376ae03840b347c3081d359a9b4469c5f93b649c40ecb578eec3d3605dd5d0ea3f635623ac310ce2f336ce2124a56aba6d23d0dd819d69fb3e584036
• Download URL:
  https://stacks.cdc.gov/view/cdc/224783/cdc_224783_DS1.pdf
• File Type:
  [PDF - 417.30 KB ]