Mortality among workers exposed to toluene diisocyanate in the US polyurethane foam industry: update and exposure-response analyses

Details

• Personal Author:
  Daniels, Robert D. ; Fent, Kenneth W. ; Pinkerton LE ; Yiin JH
• Description:
  Background: Mortality among 4,545 toluene diisocyante (TDI)-exposed workers was updated through 2011. The primary outcome of interest was lung cancer. Methods: Life table analyses, including internal analyses by exposure duration and cumulative TDI exposure, were conducted. Results: Compared with the US population, all cause and all cancer mortality was increased. Lung cancer mortality was increased but was not associated with exposure duration or cumulative TDI exposure. In post hoc analyses, lung cancer mortality was associated with employment duration in finishing jobs, but not in finishing jobs involving cutting polyurethane foam. Conclusions: Dermal exposure, in contrast to inhalational exposure, to TDI is expected to be greater in finishing jobs and may play a role in the observed increase in lung cancer mortality. Limitations include the lack of smoking data, uncertainty in the exposure estimates, and exposure estimates that reflected inhalational exposure only. [Description provided by NIOSH]
• Subjects:
  Isocyanates Lung Lung Diseases Mortality Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety Skin Toluene

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• Keywords:
  Author Keywords: Toluene Diisocyanate Cancer Cancer Rates Cohort Studies Dermal Exposures Diisocyanates Dose Response Employee Exposure Exposure-response Life Table Analysis System LTAS Lung Cancer Mortality Mortality Data Mortality Rates Mortality Studies Polyurethane Foams Skin Exposure Toluenes

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  8
• NIOSHTIC Number:
  nn:20048259
• Citation:
  Am J Ind Med 2016 Aug; 59(8):630-643
• Contact Point Address:
  Lynne E. Pinkerton, MD, MPH, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 1090 Tusculum Ave., R-15, Cincinnati, OH 45226
• Email:
  lep5@cdc.gov
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e920da9e606990a55b1309d70dd3552fc8450edeb2c01f29f36b85be71983431b2bacdcbae1abcb91965ac96e993f1036c11fd8286a97d87b6aca7b0a8d0ec5
• Download URL:
  https://stacks.cdc.gov/view/cdc/203061/cdc_203061_DS1.pdf
• File Type:
  [PDF - 137.41 KB ]