Chlorotrifluoroethylene Nephrotoxicity in Rats: A Subacute Study

Details

• Personal Author:
  Buckley LA ; Clayton JW ; Gandolfi AJ ; Nagle RB
• Description:
  Male Fischer-344 rats were exposed via inhalation to a sublethal concentration (395 ppm +/- 33 ppm; 1882 mg/m3) of the nephrotoxin chlorotrifluoroethylene (CTFE) for 4 h per day for 5 consecutive days. Within 1 day after the first exposure, rats exhibited diuresis, increased water intake, decreased urine osmolality, increased urinary lactic dehydrogenase activity and increased plasma creatinine and urea nitrogen. When animals were exposed repeatedly, values for these parameters declined or returned to control levels during the exposure sequence in a manner comparable to rats receiving the single exposure. By the third day post exposure, coagulative necrosis involving primarily the pars recta, but extending to the pars convoluta, of the proximal tubule was present. Regeneration was apparent by the third day of exposure, and additional necrosis was minimal despite further exposures. Daily levels of urinary inorganic fluoride, an index of CTFE metabolism, were increased to 3-6 micromoles/24h/rat during the exposure sequence which coincided with a brief elevation in serum fluoride at the end of each exposure. Adaptation to CTFE is evident either through changes in the metabolism or disposition of CTFE or from a refractive property of the regenerating tissue to CTFE. [Description provided by NIOSH]
• Subjects:
  Animals Kidney Diseases Occupational Health Respiratory System Safety Toxicology Urogenital Diseases Urogenital System
• Keywords:
  Animal Studies Inhalation Studies Kidney Toxins Nephrotoxicity Nephrotoxins Toxic Effects
• ISSN:
  0272-0590
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  181-186
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:20061100
• Citation:
  Fundam Appl Toxicol 1982 Jul-Aug; 2(4):181-186
• CAS Registry Number:
  Chlorotrifluoroethylene (CAS RN 79-38-9)
• Federal Fiscal Year:
  1982
• Performing Organization:
  University of Arizona
• Peer Reviewed:
  True
• Start Date:
  19820701
• Source Full Name:
  Fundamental and Applied Toxicology
• End Date:
  19850630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:705302b21f104ba4d1f97f26a05d9786df40a7baa869be62ace3a2f571b2af38a21d9d4d487523fcba582a8beb980a45860f2481c7e125f3820e02639c68a0c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/224766/cdc_224766_DS1.pdf
• File Type:
  [PDF - 659.81 KB ]