Comparison of Biological Effects with Albumin Adducts of 4,4′-Methylenediphenyl Diisocyanate in Workers

Details

• Personal Author:
  Bernstein DI ; Lummus ZL ; Sabbioni G ; Vanimireddy LR
• Description:
  Lung sensitization and asthma are the main health effects of 4,4'-methylenediphenyl diisocyanate (MDI). Albumin adducts (isocyanate-specific adducts) of MDI might be involved in the etiology of sensitization reactions. Albumin adducts of MDI were analyzed in sera of diisocyanate-exposed worker with and without diisocyanate occupational asthma (DA), as well as in exposed workers with and without diisocyanate-specific IgG antibodies. In DA-positive workers and IgG-positive workers, albumin adducts were significantly higher versus workers without DA and those who were specific IgG negative. The odds ratio to be DA-positive was 57 times larger for workers with adduct levels above 230 fmol/mg. The odds ratio to be IgG-positive was 10 times larger for workers with adduct levels above 113 fmol/mg. Therefore, albumin adducts appear to be a good predictor of the biological effects. The albumin-adduct levels in workers without biological effects were in the range of the adduct levels found in previous studies of healthy MDI-factory and construction site workers. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Hypersensitivity Isocyanates Lung Lung Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  4,4-Methylene Diphenyl Diisocyanate Albumin Adducts Author Keywords: Biomonitoring Biological Effects Biomonitoring Diisocyanates Health Effects Lung Disorders Occupational Asthma Occupational Exposure Sensitization

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• ISSN:
  0340-5761
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Louisiana ; Ohio ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  91
• Issue:
  4
• NIOSHTIC Number:
  nn:20060999
• Citation:
  Arch Toxicol 2017 Apr; 91(4):1809-1814
• Contact Point Address:
  Gabriele Sabbioni, Institute of Environmental and Occupational Toxicology, Casella Postale 108, 6780 Airolo, Switzerland
• Email:
  gabriele.sabbioni@bluewin.ch
• CAS Registry Number:
  Diphenylmethane diisocyanate (CAS RN 101-68-8)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Archives of Toxicology
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:562932b7b321999984d93284bbdc64cd2626b63ba2243ca97f6d5bcbeb08b0a6d7d0e23ca11dea8876f6cfe8c3592881f6e74d171cdfa91a04902abf6dbaa9e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/224707/cdc_224707_DS1.pdf
• File Type:
  [PDF - 438.10 KB ]