Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE): Study Design

Details

• Personal Author:
  Crowley G ; Kwon S ; Lam R ; Liu M ; Nolan A ; Oskuei A ; Prezant D ; Riggs J ; Sevick MA ; St. Jules D
• Description:
  PURPOSE: After the World Trade Center (WTC) disaster, Fire Department of New York (FDNY) rescuers suffered symptomatic loss of FEV1 below the lower limit of normal (LLN). In prior work, we identified and validated serum biomarkers predictive of abnormal FEV1, and showed that the metabolome differs in those developing WTC-Lung Injury (WTC-LI). We aim to modify these phenotypic profiles using a dietary intervention. Hypothesis: A Calorie-Restricted Mediterranean (LoCalMed) diet will alter metabolic biomarkers, improve lung function, and ultimately enhance quality of life (QOL) in firefighters with WTC-LI. METHODS: The FIREHOUSE study is an un-blinded technology-supported dietary intervention randomized clinical trial (RCT). We aim to randomize 140 FDNY firefighters to either control or LoCalMed 6-month diets. The intervention group will engage in technology assisted behavioral/nutritional/exercise monitoring with feedback, and social cognitive theory (SCT)-based group counseling sessions. Inclusion criteria are male sex, WTC-exposure, FEV1< LLN post 9/11, BMI>27 kg/m2, and signed research consent. RESULTS: Primary outcome measure is forced expiratory volume in 1 sec (FEV1). Secondary outcomes include BMI, lipidemia, targeted biomarkers (metabolome), QOL measures, FeNO, and pulse wave velocity (PWV). Pre/Post intervention blood sampling (clinical and targetable biomarkers); stool samples (microbiome); saliva (genomics); vital signs; body fat analysis; and electrocardiograms will be analyzed for significance. CONCLUSIONS: Technology-supported educational and behavioral intervention targeting calorie restriction for weight loss using a Mediterranean-style diet may improve WTC-associated loss of lung function. CLINICAL IMPLICATIONS: Successful completion of this RCT will provide a clinically relevant dietary modification and may help identify pathways of interest in future mechanistic work. [Description provided by NIOSH]
• Subjects:
  Biomarkers Diet Emergency Responders Energy Metabolism Firefighters Lung Occupational Health Particulate Matter Respiratory System Safety September 11 Terrorist Attacks

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• Keywords:
  Dietary Effects Fire Fighters First Responders Lung Function Metabolic Effects Nutrition Particulates World Trade Center WTC
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  155
• Issue:
  4
• NIOSHTIC Number:
  nn:20066280
• Citation:
  Chest 2019 Apr; 155(4)(Suppl):227A
• Federal Fiscal Year:
  2019
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  Chest
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:926252297b7f36cf972b60ecdb37888f22921276b952567a06bda56ae122d07ce1d5d45a7d98f5746de68fcaa1aa1d257f792475fd958406e481ac816fe6d710
• Download URL:
  https://stacks.cdc.gov/view/cdc/212758/cdc_212758_DS1.pdf
• File Type:
  [PDF - 95.01 KB ]