Quantitation of Cutaneous Langerhans Cells of Sarcoidosis Patients

Details

• Personal Author:
  Berman B ; Fox JL ; France DS ; Reed ML ; Teirstein AS
• Description:
  Langerhans cells play a role in cell-mediated immune reactions which are often depressed in sarcoidosis. We examined the epidermis of 17 anergic patients with sarcoidosis (Kveim-reactive and/or biopsy-proved) for the number of Langerhans cells in noninvolved skin and in any cutaneous sarcoidal lesions. Skin biopsies of 10 healthy volunteers served as controls. In comparison to controls, the epidermis overlying noninvolved (p < 0.05), sarcoidal (p < 0.0005), and Kveim-reactive (p < 0.005) skin contained significantly fewer detectable Ia and T6 antigen-bearing Langerhans cells. The reductions within noninvolved skin were most pronounced in patients with multisystem disease. Lower epidermal Langerhans cell densities, in comparison to controls, were detected in both prednisone-treated and untreated patients. Epidermis overlying sarcoidal skin of untreated patients contained significantly fewer Ia and T6 antigen-bearing Langerhans cells (p < 0.05, p < 0.0025, respectively) than epidermis from noninvolved skin. Whether reduced numbers of cutaneous Langerhans cells are due to either a local and/or systemic effect of sarcoidosis, or reflect the anergic state of these patients is unknown. [Description provided by NIOSH]
• Subjects:
  Anatomy Antigens Immune System Occupational Health Safety Skin
• Keywords:
  Humans Immune System Sarcoidosis Skin Lesions Skin Tests
• ISSN:
  0022-202X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  472-475
• Volume:
  80
• Issue:
  6
• NIOSHTIC Number:
  nn:20060774
• Citation:
  J Invest Dermatol 1983 Jun; 80(6):472-475
• Contact Point Address:
  Dr. Brian Berman, Dermatology Service, V.A. Medical Center, 150 Muir Road, Martinez, California 94553
• Federal Fiscal Year:
  1983
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Investigative Dermatology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:355acc43face3a66284fa3a0342c669a1597314a1a73cba67719a6a2df0d24a0363665328bf0d14f2baaeb2e14e78a8b6edab1c1c709fc6f17aed624694e6aaf
• Download URL:
  https://stacks.cdc.gov/view/cdc/224595/cdc_224595_DS1.pdf
• File Type:
  [PDF - 2.54 MB ]