Association of Low FVC Spirometric Pattern with WTC Occupational Exposures

Details

• Personal Author:
  Celedon JC ; de la Hoz RE ; Lucchini RG ; Nolan A ; Shapiro M ; Szeinuk J
• Description:
  Background: A reduced forced vital capacity without obstruction (low FVC) is the predominant spirometric abnormality reported in workers and volunteers exposed to dust, gases, and fumes at the World Trade Center (WTC) disaster site in 2001-2002. While low FVC has been associated with obesity and metabolic syndrome, its association with WTC occupational exposures has not been demonstrated. We estimated the prevalence of this abnormality and examined its association with WTC exposure level. Methods: Longitudinal study of the relation between arrival at the WTC site within 48 h and FVC below the lower limit of normal (FVC < LLN, with normal FEV1/FVC ratio) at any time in 10,284 workers with at least two spirometries between 2002 and 2018. Logistic regression and linear mixed models were used for the multivariable analyses. Results: The prevalence of low FVC increased from 17.0% (95% CI 15.4%, 18.5%) in June 2003, to 26.4% (95% CI 24.8%, 28.1%) in June 2018, and exceeded at both times that of obstruction. The rate of FVC decline was - 43.7 ml/year during the study period. In a multivariable analysis adjusting for obesity, metabolic syndrome indicators, and other factors, early arrival at the WTC disaster site was significantly associated with low FVC, but only among men (ORadj = 1.29, 95% CI 1.17, 1.43). Longitudinal FVC rate of decline did not differ by WTC site arrival time. Conclusions: Among WTC workers, the prevalence of low FVC increased over a 16-year period. Early arrival to the WTC disaster site was significantly associated with low FVC in males. [Description provided by NIOSH]
• Subjects:
  Emergency Responders Lung Occupational Health Respiratory Function Tests Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  2001 Author Keywords: Occupational Lung Disease Emergency Responders First Responders Longitudinal Changes In Lung Function Lung Function Metabolic Disorders Obesity Rescue Workers Smoke Inhalation Injury Spirometry World Trade Center World Trade Center Attack WTC

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• ISSN:
  0954-6111
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  170
• NIOSHTIC Number:
  nn:20060791
• Citation:
  Respir Med 2020 Aug-Sep; 170:106058
• Contact Point Address:
  Rafael E. de la Hoz, Division of Occupational Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, WTC HP CCE Box 1059, New York, NY, 10029
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Respiratory Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b402702bab984f5e95b4157f79b52fede613221de5d06c8e84f3aeae8a1aad150e2f12399b3e3145d6e10e254ec7aba8e2bc74cf1377df03d54b632a2a7c611f
• Download URL:
  https://stacks.cdc.gov/view/cdc/224604/cdc_224604_DS1.pdf
• File Type:
  [PDF - 513.53 KB ]