Cluster Analysis of World Trade Center Related Lower Airway Diseases

Details

• Personal Author:
  Celedón JC ; de la Hoz RE ; Doucette JT ; Jeon Y ; Reeves AP ; San José Estépar R ; Weber J
• Description:
  Introduction: Cluster analysis can classify without a priori assumptions the heterogeneous chronic lower airway diseases found in former workers at the World Trade Center (WTC) disaster site. Methods: We selected the first available chest computed tomography scan with quantitative computed tomography measurements on 311 former WTC workers with complete clinical, and spirometric data from their closest surveillance visit. We performed a nonhierarchical iterative algorithm K-prototype cluster analysis, using gap measure. Results: A five-cluster solution was most satisfactory. Cluster 5 had the healthiest individuals. In cluster 4, smoking was most prevalent and intense but there was scant evidence of respiratory disease. Cluster 3 had symptomatic subjects with reduced forced vital capacity impairment (low FVC). Clusters 1 and 2 had less dyspneic subjects, but more functional and quantitative computed tomography evidence of chronic obstructive pulmonary disease (COPD) in cluster 1, or low FVC in cluster 2. Clusters 1 and 4 had the highest proportion of rapid first-second forced expiratory volume decliners. Conclusions: Cluster analysis confirms low FVC and COPD/pre-COPD as distinctive chronic lower airway disease phenotypes on long-term surveillance of the WTC workers. [Description provided by NIOSH]
• Subjects:
  Lung Occupational Health Respiratory Function Tests Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  2001 Author Keywords: Occupational Lung Disease Chronic Obstructive Pulmonary Disease COPD Longitudinal Changes In Lung Function Lung Function Smoke Inhalation Injury Spirometry Surveillance World Trade Center World Trade Center Attack WTC

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  179-184
• Volume:
  66
• Issue:
  2
• NIOSHTIC Number:
  nn:20069197
• Citation:
  J Occup Environ Med 2024 Feb; 66(2):179-184
• Contact Point Address:
  Rafael E. de la Hoz, MD, MPH, MSc, Division of Occupational and Environmental Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, WTC HP CCE Box 1059, New York, NY 10029
• Email:
  Rafael.delaHoz@mssm.edu
• Federal Fiscal Year:
  2024
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20120901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dd09444619f06e89f4cc0d1cdef4afb84754983c8ac29fe2da7a4decdbb770fb97b38f1024ae69d12277f77e3afd998347b6b4a6ad328dfca927353a8bb05ce2
• Download URL:
  https://stacks.cdc.gov/view/cdc/207725/cdc_207725_DS1.pdf
• File Type:
  [PDF - 308.18 KB ]