Bioassay for Carcinogenicity of 3,2′-Dimethyl-4-Nitrosobiphenyl, O-Nitrosotoluene, Nitrosobenzene and the Corresponding Amines in Syrian Golden Hamsters

Details

• Personal Author:
  El-Bayoumy K ; Fiala ES ; Hecht SS ; Rivenson A
• Description:
  3,2'-Dimethyl-4-aminobiphenyl and 3,2'-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with 3,2'-dimethyl-4-aminobiphenyl, 24 animals had bladder tumors. In the group treated with 3,2'-dimethyl-4-nitrosobiphenyl 25 animals had subcutaneous tumors and 2 had bladder tumors. These results indicate that 3,2'-dimethyl-4-nitrosobiphenyl is a potent locally acting carcinogen. Total doses of 99 mmol/kg of aniline, o-toluidine, nitrosobenzene, or o-nitrosotoluene administered by subcutaneous injection failed to induce tumors. [Description provided by NIOSH]
• Subjects:
  Animals Biological Assay Carcinogens Occupational Health Safety
• Keywords:
  Animal Studies Bioassays Bladder Cancer Nitroso Compounds O-Nitrotoluene
• ISSN:
  0304-3835
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  349-354
• Volume:
  20
• Issue:
  3
• NIOSHTIC Number:
  nn:20060694
• Citation:
  Cancer Lett 1983 Oct; 20(3):349-354
• Federal Fiscal Year:
  1984
• Performing Organization:
  American Health Foundation, Valhalla, New York
• Peer Reviewed:
  True
• Start Date:
  19751201
• Source Full Name:
  Cancer Letters
• End Date:
  19811130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:67e471a4d1f457636be3153dd607f704b10e0aae250aedb1e2976111a59da061ef63e74d30c687e884f98925b20e23aa71bfc9929d57c2ce316052ad92281bc5
• Download URL:
  https://stacks.cdc.gov/view/cdc/224533/cdc_224533_DS1.pdf
• File Type:
  [PDF - 405.82 KB ]