Effects of Epidermal Growth Factor on Deoxyribonucleic Acid Synthesis and Stomach Weight in Hypophysectomized Adult Mice

Details

• Personal Author:
  Lopez R ; Pauly JE ; Scheving LA ; Scheving LE ; Tsai TH
• Description:
  The effect of EGF on the incorporation of [3H]TdR into DNA (DNA synthesis) was determined in the esophagus, liver, pancreas, and kidney in mice standardized to 12 hours (hr) of light alternating with 12 hr of darkness. A question asked was whether intraperitoneally administered EGF could alter the circadian patterns of DNA synthesis in these organs. The most marked effects of EGF were: (1) an increase in DNA synthesis but only after a specific duration of time after treatment, ranging from 8 to 23 hr, which differed for each tissue, (2) a similarity in the response of the esophagus in both ad lib fed and fasted mice, but not in the response of the liver, where the stimulatory effect of EGF observed in fed mice was dramatically reduced in fasted ones, and (3) an advance in the phasing of the circadian rhythm in DNA synthesis of the esophagus by about 12 hr. In addition, no sex differences in fasted animals were found under the conditions of this study. [Description provided by NIOSH]
• Subjects:
  Animals Circadian Rhythm Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Epidermal Growth Factor Biological Rhythms Circadian Circadian Rhythms Corneal Epithelium Deoxyribonucleic Acids Dietary Effects DNA Hypophysectomy Mitotic Index Peptides Stomach Weight

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• ISSN:
  0196-9781
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  5
• NIOSHTIC Number:
  nn:20060607
• Citation:
  Peptides 1984 Sep-Oct; 5(5):945-951
• Contact Point Address:
  L. A. Scheving, Department of Pathology, Stanford University Medical Center, Palo Alto, CA 94305
• Federal Fiscal Year:
  1984
• Performing Organization:
  University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Peptides
• End Date:
  19880301
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:27b71fcbe362e07fd061006d894fff026a258f5e33019d466ffe715f65ee48dea815228a200670cf2158a883ac9a8d14f45a58b543f8a57946e5e80c1cdd1a5a
• Download URL:
  https://stacks.cdc.gov/view/cdc/224465/cdc_224465_DS1.pdf
• File Type:
  [PDF - 536.87 KB ]