Temporal Correlation of Some Endocrine Circadian Rhythms in Elderly Subjects

Details

• Personal Author:
  Althoff P ; Cugini P ; Franke H ; Halberg F ; Letizia C ; Lucia P ; Maldonato A ; Murano G ; Pusch H-J ; Rosak C ; Scavo D ; Schramm A ; Shöffling K ; Tamburrano G ; Tomassini R
• Description:
  The aim of this chronobiological study was to investigate temporal correlations in the circadian patterns of 6 hormones, namely somatotrophic hormone (STH), prolactin (PRL), cortisol (F), aldosterone (ALD), insulin (IRI) and C-peptide (CP), assayed in systemic blood serum drawn at 07:00, 10:00, 13:00, 16:00, 19:00 and 22:00 h from an antecubital vein in 19 young subjects (aged 20-29 yr, comprising 10 males and 9 females; and 20 elderly subjects (aged 70-81 yr, comprising 10 males and 10 females). All subjects were sampled on a normal dietary sodium intake (120-140 mEq/24h) while following a social routine of diurnal activity (07:00-23:00) and nocturnal rest (23:00-07:00). Time-qualified data were analyzed by lead-lag correlation and by cosinor analysis. According to the lead-lag correlation findings, it would appear that the correlation which exists between several time-qualified series in young subjects is no longer present in elderly subjects. The circadian rhythms which were found to have lost their temporal correlations with advancing age were those between STH and IRI, STH and ALD, PRL and IRI, PRL and CP, and ALD and CP. It should be noted that the correlation between hormonal rhythms breaks down mainly on account of a peculiar age-related change in the magnitude of the circadian fluctuation. This chronological decline in amplitude led to the conclusion that the senescence of endocrine rhythmic functions is a biological phenomenon characterized by altered circadian variability. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Circadian Rhythm Occupational Health Safety
• Keywords:
  Age Factors Ageing Author Keywords: Aldosterone Biological Rhythms Biorhythm C-peptide Circadian Rhythms Cortisol Dietary Effects Endocrine Function Endocrine System Hormone Activity Insulin Prolactin Somatotrophic Hormone

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• ISSN:
  0378-5122
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  175-186
• Volume:
  7
• Issue:
  2
• NIOSHTIC Number:
  nn:20060492
• Citation:
  Maturitas 1985 Jul; 7(2):175-186
• Contact Point Address:
  Professor Pietro Cugini, I Patologia Medica, c/o II Clinica Medica, Policlinico Umberto I, 00161 Rome, Italy
• Federal Fiscal Year:
  1985
• Performing Organization:
  University of Minnesota of Minneapolis-St Paul, Minneapolis, Minnesota
• Peer Reviewed:
  True
• Start Date:
  19770801
• Source Full Name:
  Maturitas
• End Date:
  19860331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d11087ce24f85f9e5e10895ad8c06dc54c2f67daf38bf3c9a83a6ebd7352903507717e92567ebdc3ebe8ae9c2b99f0cbacb6a585a119de89382925914c26615c
• Download URL:
  https://stacks.cdc.gov/view/cdc/224367/cdc_224367_DS1.pdf
• File Type:
  [PDF - 825.99 KB ]