Ethylene Dibromide: Effects of Paternal Exposure on the Neurotransmitter Enzymes in the Developing Brain of F1 Progeny

Details

• Personal Author:
  Adams PM ; Fanini D ; Hsu LL ; Legator MS
• Description:
  The effects of ethylene dibromide (EDB) exposure to male rats on several neurotransmitter enzymes have been examined in various brain regions of the F1 progeny, from 7 to 90 days of age. The choline acetyltransferase activity was significantly increased at 21 days old, in most brain regions studied in the F1 progeny of the EDB-treated males, but not at 7, 14 or 90 days old. The acetylcholinesterase activity was altered in different brain regions of the F1 progeny of the EDB-exposed males at both 14 and 21 days old but not at 7 or 90 days old. Glutamic acid decarboxylase activity was increased in corpus striatum but decreased in frontal cortex only at 21 days of age. These neurochemical changes in the developing brain of F1 progeny of EDB-treated males at low doses may be associated with behavioral abnormalities observed early in their development. [Description provided by NIOSH]
• Subjects:
  Animals Behavior Biochemistry Occupational Health Safety
• Keywords:
  Animal Studies Brain Function Ethylene Dibromide Neurological System Neurotransmitters
• ISSN:
  0027-5107
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  197-203
• Volume:
  147
• Issue:
  4
• NIOSHTIC Number:
  nn:20060478
• Citation:
  Mutat Res 1985 Aug; 147(4):197-203
• Contact Point Address:
  Louise L. Hsu, Ph.D., Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77550, U.S.A.
• CAS Registry Number:
  1,2-Dibromoethane (CAS RN 106-93-4)
• Federal Fiscal Year:
  1985
• Performing Organization:
  University of Texas Med BR Galveston, Galveston, Texas
• Peer Reviewed:
  True
• Start Date:
  19810401
• Source Full Name:
  Mutation Research
• End Date:
  19880331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:21707a0e0e0ab10ac8678596dde8f916976e57a3f77215070e0506d4634488d6ba0d9b36e4b49b6040d808b0c2e62eab67af4c032b3d7ffed78fcf9a476c1b65
• Download URL:
  https://stacks.cdc.gov/view/cdc/224355/cdc_224355_DS1.pdf
• File Type:
  [PDF - 469.24 KB ]