DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

Details

• Personal Author:
  Cheramy A ; Cole DG ; Cooper DC ; Corbett R ; Fienberg AA ; Girault JA ; Grace AA ; Greengard P ; Haile CN ; Hiroi N ; Hyman SE ; Mermelstein PG ; Miller DB ; Nestler EJ ; Nishi A ; O'Callaghan JP ; Onn SP ; Ouimet CC ; Snyder GL ; Song WJ ; Surmeier DJ ; White FJ
• Description:
  Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission. [Description provided by NIOSH]
• Subjects:
  Animals Behavior Nervous System Occupational Health Safety
• Keywords:
  Animal-studies Behavior-patterns Brain-function Brain-matter Drug-interaction Drugs Molecular-biology Molecular-structure Proteins
• ISSN:
  0036-8075
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  282
• Issue:
  5378
• NIOSHTIC Number:
  nn:20025211
• Citation:
  Science 1998 Aug; 282(5378):838-842
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f1ba95e5f2c21e15a24d8874957cfeed562304c264e8bc8442d881844d161d67c242ea57933166afc333338ac88153defa56df7e02825c97962b3c0bdee6328d
• Download URL:
  https://stacks.cdc.gov/view/cdc/196682/cdc_196682_DS1.pdf
• File Type:
  [PDF - 215.51 KB ]